Latest critical summaries from the American Dental Association Center for Evidence-based Dentistry


Two new critical summaries are now available from the ADA-EBD website.

First is a summary of a 2012 systematic review by Zandbergen et al that looked the systemic administration of amoxicillin and metronidazole as an adjunct to scaling and root planning (Dental Elf 25th May 2012). The review notes that there was no comparison in this review with scaling and root planning alone and that adverse events were not addressed.  In our May 2012 Dental Elf blog we also highlighted 7 other similar recent reviews.

The second summarises a 2010 review by Waasdorp that considered whether the presence of infection compromised the osseointegration of  implants placed immediately into an extraction site.  The appraiser noted that only a small number of low quality studies involving small numbers of implants were available.  While the review suggests over 90% success at one year the supporting evidence is currently weak.


ADA-EBD – Indirect evidence provides poor evidence in support of concomitant use of amoxicillin/metronidazole to improve periodontal measures

Zandbergen D, Slot DE, Cobb CM, Van der Weijden FA. The Clinical Effect of Scaling and Root Planing and The Concomitant Administration of Systemic Amoxicillin and Metronidazole: A Systematic Review. J Periodontol. 2012 May 21. [Epub ahead of print] PubMed PMID: 22612369.

The Dental Elf 25th May 2012 – Systemic antibiotics as an adjunct to non-surgical periodontal treatment

The Dental Elf 31st Oct 2012 Weak evidence suggests small additional benefit from the use of local antimicrobials as adjunct to scaling and root planning for chronic periodontitis patients


ADA-EBD – Poor evidence exists for success with immediate placement of dental implants into infected sites

Waasdorp JA, Evian CI, Mandracchia M. Immediate placement of implants into infected sites: a systematic review of the literature. J Periodontol. 2010 Jun;81(6):801-8. doi: 10.1902/jop.2010.090706. Review. PubMed PMID: 20192616.



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Derek Richards

Derek Richards is a specialist in dental public health, Director of the Centre for Evidence-Based Dentistry and Specialist Advisor to the Scottish Dental Clinical Effectiveness Programme (SDCEP) Development Team. A former editor of the Evidence-Based Dentistry Journal and chief blogger for the Dental Elf website until December 2023. Derek has been involved with a wide range of evidence-based initiatives both nationally and internationally since 1994. Derek retired from the NHS in 2019 remaining as a part-time senior lecturer at Dundee Dental School until the end of 2023.

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