Third molars: Distal caries development in adjacent second molars

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In 2000  guidance from NICE ( National Institute of Health and Care Excellence)  recommended that ‘The practice of prophylactic removal of pathology-free impacted third molars should be discontinued in the NHS’.  As a result the numbers of third molars extracted has declined and it has been suggested that the increased retention of third molars has contributed to an increase in distal surface caries (DSC) in second permanent molars.

The main aim of this review was to assess the prevalence of distal surface caries (DSC) in second permanent molars associated with retained third molars.

Methods

Searches were conducted in the Cochrane Library, Embase, Medline and LILACS databases with no restrictions on language or date of publication. Prospective and retrospective studies assessing the prevalence of DSC in second molars were considered.  Three reviewers screened titles all with papers being reviewed by two. Data was extracted independently with study quality assessed using a validated tool for prevalence studies.  Pooled prevalence estimates and 95% confidence intervals (CI) were calculated and random effects meta-analysis conducted.

 Results

  • 11 studies (4 prospective, 7 retrospective) were included.
  • 6 studies were from Asia, 3 Europe, 2 South America.
  • All the studies were conducted in hospitals.
  • Prevalence ranged from 4.5% to 52% (11,452 second molars).
  • Data from meta-analysis is summaries in the table.
  Prevalence ( 95%CI)
Overall Pooled 23% (2% to 44%)
Prospective studies 20% (5% to 36%)
Retrospective studies 15% (5% to 36%)
Mesial impactions 36% (5% to 67%)
Horizontal Impactions 22% (1% to 42%)
Distal Impactions 3%   (1% to 5%)
Vertical impactions 7%   (1% to 13%)
  • European studies suggested that DSC may be present in about one in four referrals for the assessment of third molars, and that the risk is considerably higher in those with convergent third molar impactions.

Conclusions

The authors concluded: –

The meta-analysis showed a 23% pooled prevalence of DSC among patients (DSC therefore affects about one in four of those referred). The confidence intervals, however, were wide (44% to 2%), which suggests a lack of precision. We also detected considerable heterogeneity and suggest that this may be caused by several factors that are linked to differences in practice.

Ultimately, to improve estimates of the prevalence of DSC and to find answers to our secondary objectives, larger well-reported observational studies are needed, but research funding might be better spent on interventional studies that show how best to manage impacted third molars and their consequences

Comments

The authors have searched a good range of databases. 6 studies use panoramic x-rays in addition to clinical examination however they have poor sensitivity and sensitivity for caries as noted by the authors. A majority of the studies were retrospective using clinical note and records for assessment All of the included studies were conducted on hospital patients so the prevalence estimates may not be representative of the general population. The diagnostic criteria for caries vary between the included studies which may also have implications for the prevalence rates.   The overall pooled prevalence for DSC was estimated to be 23% however the confidence intervals were very wide (2% to 44%).  As suggested by the authors the quality of the available is limited and data from high quality prospective data would be very helpful. For while work had started on updating the NICE 2000 guidance  that work has currently been deprioritised.

Links

Primary Paper

Toedtling V, Devlin H, Tickle M, O’Malley L. Prevalence of distal surface caries in the second molar among referrals for assessment of third molars: a systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2019 May 22. pii:S0266-4356(19)30159-7. doi: 10.1016/j.bjoms.2019.04.016. [Epub ahead of print]Review. PubMed PMID: 31128951.

Other references

NICE – Guidance on the extraction of wisdom teeth

 

 

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