Atypical antipsychotic medications, sometimes described as second generation (for example clozapine, risperidone) have been associated with a number of side effects amongst which is weight gain. The authors of this review point out that such weight gain can be significant in people with learning disabilities using such medications.

Previous studies have shown that majority of people treated with atypical antipsychotic medication can gain at least 10% of their initial body weight over the course of therapy. Genetic constitution is an important factor influencing weight gain.

The authors review the existing literature on psychopharmacogenetics of atypical antipsychotic-induced weight gain and the importance of this research for individuals with learning disabilities.

Why research on the pharmacogenetics of atypical antipsychotic-induced weight gain in individuals with intellectual disabilities is warranted, Sleister H & Valdovinos M in Journal of Mental Health Research in Intellectual Disabilities, 4, 2, 65-78