Human pregnancy is considered to be full-term when it lasts between 37-42 weeks. Anything shorter is considered to be a pre-term birth and anything longer is considered post-term. Longer pregnancies can be a risk to both the mother and infant and so labour tends to be induced if a pregnancy goes on past 42 weeks. On the other hand, it is well-documented that pre-term babies can have a variety of mental health problems (see previous Mental Elf blogs: refs 2-3).
However, considering all babies born between 37-42 weeks as a single group ignores the variability of developmental outcomes of these children. For example, a child born at 41 weeks is likely to be more physically and mentally developed and weigh substantially more than a child born at 37 weeks. In fact, there is some research suggesting that the short-term outcomes of children born between 37-39 weeks are worse than those born after 39 weeks, including a greater risk of not surviving infanthood. There has been less research exploring the longer-term developmental outcomes of such ‘early-term’ infants (37-39 weeks). The authors of a recent research article performed a systematic review to summarise what is known about this issue.
A number of electronic research databases were searched using a list of relevant keywords. Articles were selected for the review if:
- The participants included early-term infants (37-39 weeks) and full-term infants
- Long-term developmental outcomes were reported for both groups
- The data and methods were reported adequately
11 studies (mostly large population-based cohort studies) met these criteria and were included in the review. Quality of the studies was assessed by 2 independent researchers.
The long-term developmental outcomes assessed by the various studies focused on:
- Neurodevelopment (general intelligence, presence of cerebral palsy)
- Academic problems (difficulties in mathematics, reading, spelling, exam performance, attending a special needs school)
- Behavioural and emotional problems (any psychiatric diagnosis, receiving medication for ADHD)
When the same outcome was reported by more than one study, a meta-analysis was performed to determine whether there was an overall effect.
Only 2 outcomes were assessed in a comparable way by more than one study. Using meta-analysis, the authors report that early-term infants have a higher risk of cerebral palsy and of mathematical difficulties.
Other outcomes were only assessed by a single study or not comparable across studies. Yet on the whole, they suggested that individuals who were born early-term (37-39 weeks) had generally somewhat poorer developmental outcomes than those with a gestational age of a few additional weeks. Although when additional factors were considered (such as maternal education or socioeconomic status), the effects reported by the individual studies decreased.
The authors concluded that amongst the group of infants born at full-term (that is, between 37-42 weeks of gestation), those born earlier appear to have an increased risk for poorer long-term academic and social outcomes.
The authors also note that it would seem that post-natal environment and family situation may help attenuate negative effects resulting from an early-term birth. Further work is needed to determine whether long-term follow-up and appropriate interventions for early-term infants will improve their outcomes.
- The studies reviewed assessed a variety of different outcomes, many of which could not be compared directly using meta-analyses.
- The participants were assessed across a long span of ages (4-29 years).
- The meta-analyses contained only a very small number of studies.
- Although the quality of the studies was generally deemed to be good, the studies did not all adequately assess long-term loss of participants at follow-up (i.e. dropping out of the study), which may have affected those with poor outcomes more.
- Although the authors used relevant key words and searched a number of databases, a more comprehensive list of search terms (for example including “gestation” or “gestational age”) may have resulted in additional studies being found and included.
Given these limitations, these results are preliminary and more research is needed to clarify more definitively the risk of poor long-term outcomes in early-term infants. It is also not yet clear what the mechanisms by which early-term birth might affect long-term development are.
A preliminary review of the scientific literature suggests that the long-term academic and social outcomes of early-term infants (born at 37-39 weeks of gestation) are potentially poorer than those of children born a few weeks later. As such, these babies and their parents might require some additional care and support from healthcare and social agencies to help them reach their full developmental potential.
- Dong Y, Chen SJ, and Yu JL. A Systematic Review and Meta-Analysis of Long-Term Development of Early Term Infants. Neonatology 2012; 102(3): 212-221.
- Premature babies have greater risk of serious mental illness. The Mental Elf, 6 Jun 2012.
- Low birth weight or preterm babies have an increased risk of personality disorders. The Mental Elf, 14 Aug 2012.
The difference of a few weeks in the womb: do early-term infants have poorer developmental outcomes? – http://t.co/TT2iyPZRlC
Congratulations to @trufflesquirrel for her first blog about the developmental outcomes of premature babies http://t.co/pJfG7MSA0W
Systematic review: “Early-term infants have a higher risk of cerebral palsy & of mathematical difficulties” http://t.co/pJfG7MSA0W
My first post for @Mental_Elf The difference of a few weeks in the womb: do early-term infants have poorer outcomes? http://t.co/RgSKPHrBzd
The long-term academic & social outcomes of early-term infants are poorer than babies born later http://t.co/pJfG7MSA0W
@Mental_Elf Interesting research, I was born 2mnths prem and have always struggled with spelling and small maths issues-can do stats though!
New Chinese meta-analysis explores the long-term development of early term infants http://t.co/pJfG7MSA0W @trufflesquirrel
“The difference of a few weeks in the womb: do early-term infants have poorer developmental outcomes? http://t.co/lexsPRbtbO” @pariahrob
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