Mortality rates in anorexia nervosa, bulimia nervosa and eating disorder not otherwise specified: new meta-analysis

iStock_000015812154XSmall eating disorders fork with a lock

The rates of morbidity and mortality in eating disorders are thought to be high, but the exact rates were not known before this meta analysis published in the Archives of General Psychiatry.

The authors set out to systematically compile and analyze the mortality rates in individuals with anorexia nervosa, bulimia nervosa, and eating disorder not otherwise specified (EDNOS).  They conducted a systematic literature search and selected English language peer reviewed articles published between January 1, 1966, and September 30, 2010, that reported mortality rates in patients with eating disorders.  They found 36 quantitative studies with sufficient data for extraction.

The studies reported outcomes of:

  • Anorexia nervosa during 166 642 person-years
  • Bulimia nervosa during 32 798 person-years
  • EDNOS during 22 644 person-years

The weighted mortality rates (ie, deaths per 1000 person-years) were:

  • 5.1 for anorexia nervosa
  • 1.7 for bulimia nervosa
  • 3.3 for EDNOS

The standardized mortality ratios were:

  • 5.86 for anorexia nervosa
  • 1.93 for bulimia nervosa
  • 1.92 for EDNOS

One in 5 individuals with anorexia nervosa who died had killed themselves.

The authors concluded:

Individuals with eating disorders have significantly elevated mortality rates, with the highest rates occurring in those with anorexia nervosa. The mortality rates for bulimia nervosa and EDNOS are similar. The study found age at assessment to be a significant predictor of mortality for patients with anorexia nervosa. Further research is needed to identify predictors of mortality in patients with bulimia nervosa and EDNOS.

Arcelus, J. Mitchell, AJ. Wales, J. Nielsen, N. Mortality Rates in Patients With Anorexia Nervosa and Other Eating Disorders: A Meta-analysis of 36 Studies. Arch Gen Psychiatry 2011;68(7):724-731. doi:10.1001/archgenpsychiatry.2011.74 [Abstract]

Share on Facebook Tweet this on Twitter Share on LinkedIn Share on Google+
Mark as read
Create a personal elf note about this blog
Andre Tomlin

Andre Tomlin

André Tomlin is an Information Scientist with 20 years experience working in evidence-based healthcare. He's worked in the NHS, for Oxford University and since 2002 as Managing Director of Minervation Ltd, a consultancy company who do clever digital stuff for charities, universities and the public sector. Most recently André has been the driving force behind the Mental Elf and the National Elf Service; an innovative digital platform that helps professionals keep up to date with simple, clear and engaging summaries of evidence-based research. André is a Trustee at the Centre for Mental Health and an Honorary Research Fellow at University College London Division of Psychiatry. He lives in Bristol with his wife, dog and three little elflings.

More posts - Website

Follow me here –