0.2% chlorhexidine mouthrinse gave slightly better plaque reduction than 0.12% mouthrinse

shutterstock_20760106 - mouthwash

In 2010 Berchier et al  reviewed the efficacy of two different concentrations of  chlorhexidine mouthrinse ( 0.2 & 0.12% ).  A critical appraisal of this review is now available on the American Dental Associations Evidence-based Dentistry website.

The commentator notes that a comprehensive search strategy was used although restricted to the English language. Eight studies involving 803 patients were included and a meta-analysis undertaken.  Plaque accumulation was the only outcome measure that could be compared and there was a small significant difference in favour of the 0.2% solution although the clinical relevance is probably minor.

Go to the ADA-EBD summary

Go to Evidence-based Dentistry Journal commentary

Berchier CE, Slot DE, Van der Weijden GA. The efficacy of 0.12% chlorhexidine mouthrinse compared with 0.2% on plaque accumulation and periodontal parameters: a systematic review. J Clin Periodontol. 2010 Sep;37(9):829-39. Epub 2010 Jul 7. Review. PubMed PMID: 20618550



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Derek Richards

Derek Richards is a specialist in dental public health, Director of the Centre for Evidence-Based Dentistry and Specialist Advisor to the Scottish Dental Clinical Effectiveness Programme (SDCEP) Development Team. A former editor of the Evidence-Based Dentistry Journal and chief blogger for the Dental Elf website until December 2023. Derek has been involved with a wide range of evidence-based initiatives both nationally and internationally since 1994. Derek retired from the NHS in 2019 remaining as a part-time senior lecturer at Dundee Dental School until the end of 2023.

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