Improvements in dry mouth seen with night guard and/or BET containing mouthwash


Xerostomia is a common condition that affects many adults. It is frequently caused by autoimmune diseases such as Sjögren’s syndrome and rheumatoid arthritis or as a result of drug-related side effects. The aim of the present study was to evaluate the efficacy and safety of an intraoral device and a Betaine (BET) containing mouthwash in treating xerostomia.

105 patients were randomised to one of three groups A (night guard), B (mouthwash), or C (night guard and mouthwash). All subjects reported a history of dry mouth of pharmacological origin. Patients had unstimulated salivary flow was measured and completed a xerostomia questionnaire and the Oral Health Impact Profile (OHIP)–14, before and after 4 weeks. Patient satisfaction was also recorded.Ninety patients (eight men and 82 women) completed the study.

They found that:-

  • Symptoms of xerostomia were improved, with all 3 groups showing improvements in OHIP-14 scores and sialometry findings.
  •  There were no adverse effects and no statistical differences in patient satisfaction between the 3 groups.

The authors concluded that:-

The daily use of a night guard and BET containing mouthwash was seen to improve dry mouth during the 4-week duration of the study.

López-Jornet P, Camacho-Alonso F, Rodriguez-Aguado C. Evaluation of the clinical efficacy of a betaine-containing mouthwash and an intraoral device for the treatment of dry mouth. J Oral Pathol Med. 2011 Sep 22. doi:10.1111/j.1600-0714.2011.01088.x. [Epub ahead of print] PubMed PMID: 21950587.


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Derek Richards

Derek Richards is a specialist in dental public health, Director of the Centre for Evidence-Based Dentistry and Specialist Advisor to the Scottish Dental Clinical Effectiveness Programme (SDCEP) Development Team. A former editor of the Evidence-Based Dentistry Journal and chief blogger for the Dental Elf website until December 2023. Derek has been involved with a wide range of evidence-based initiatives both nationally and internationally since 1994. Derek retired from the NHS in 2019 remaining as a part-time senior lecturer at Dundee Dental School until the end of 2023.

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