Little evidence available for the effectiveness of arginine-containing toothpastes in managing dentine hypersensitivity

shutterstock_44187316

Last year we looked at a number of studies that looked at the effectiveness of various toothpastes in reducing dentine hypersensitivity (Dental Elf 30th October 2012).  The aim of this review was to assess the effectiveness of arginine-containing desensitising toothpastes in comparison to control agents in reducing dentine hypersensitivity (DH).   The aetiology of DH is usually reported as multifactorial and while this review focuses on the use of arginine containing pastes it also provides a useful table of the various desensitizing agent together with the mechanism of action.

The reviewers searched the Medline, Cochrane Central, Embase and Lilacs databases  for randomised and controlled clinical trials. The primary outcome considered was change in pain/sensitivity reported by tactile and air-blast stimuli.  Study selection, data extraction, quality assessment and risk of bias assessment was conducted independently in duplicate.

  • Only two studies involving 243 patients in total were included.
  • Both studies were conducted by the same team.
  • One study was of 3 days duration the other of 8 weeks.
  • Both studies reported greater improvement in DH with the arginine paste.

The authors concluded

Data identified indicates a potential role for arginine-containing toothpastes in managing dentine hypersensitivity. However, this conclusion is based on small sample sizes and the studies identified did not follow patients up in the medium to long term. The authors recommend that there is a need for well-designed RCTs to be conducted prior to any definitive recommendations being made.

Links

Sharif MO, Iram S, Brunton PA. Effectiveness of arginine containing toothpastes in treating dentine hypersensitivity: A systematic Review. J Dent. 2013 Jan 31. doi:pii: S0300-5712(13)00027-4. 10.1016/j.jdent.2013.01.009. [Epub ahead of print] PubMed PMID: 23376174.

Dental Elf 30th Oct 2012 – Trial shows improvements in dentine hypersensitivity with different toothpastes


 

Share on Facebook Tweet this on Twitter Share on LinkedIn Share on Google+
Mark as read
Create a personal elf note about this blog
Profile photo of Derek Richards

Derek Richards

Derek Richards is the Director of the Centre for Evidence-based Dentistry, Editor of the Evidence-based Dentistry Journal, Consultant in Dental Public Health with Forth Valley Health Board and Honorary Senior Lecturer at Dundee & Glasgow Dental Schools. He helped to establish both the Centre for Evidence-based Dentistry and the Evidence-based Dentistry Journal. He has been involved with teaching EBD and a wide range of evidence-based initiatives both nationally and internationally since 1994.

More posts - Website

Follow me here –