ADA-EBD summary on amoxicillin/metronidazole therapy for aggressive periodontitis


This ADA-EBD critical summary looks at a systematic review from the same group that conducted the review that we highlighted yesterday (Sgolastra et al 2012).  This time the question was whether the use of amoxicillin/metronidazole (AMX/MET) as an adjunct to scaling and root planning (SRP) was more effective than SRP alone in the treatment of aggressive periodontitis.

As with the review focused on chronic periodontitis the appraisers considered that searching an analysis of the data identified was well conducted and reported.  Again only a small number of trials could be included (6) involving 183 participants,  five of these having a low risk of bias. .

The reviews findings suggested the use of AMX/MET as an adjunct to scaling and root planning  in patients with aggressive periodontitis may improve treatment outcomes.


ADA-EBD Amoxicillin/metronidazole therapy may improve the effectiveness of scaling and root planing in patients with periodontitis: aggressive

Sgolastra F, Petrucci A, Gatto R, Monaco A. Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: a systematic review and meta-analysis. J Periodontol. 2012 Jun;83(6):731-43. doi: 10.1902/jop.2011.110432. Epub 2011 Nov 3. Review. PubMed PMID: 22050545.

Dental Elf 6th June 2013  – ADA-EBD summary on  amoxicillin/metronidazole therapy for Chronic periodontitis

Dental Elf 25th May 2012  – Systemic antibiotics as an adjunct to non-surgical periodontal treatment

Dental Elf 24th Jan 2012 – Better outcomes with metronidazole and amoxicillin as an adjunct to full mouth disinfection for patients with aggressive periodontitis

Dental Elf 7th Nov 2011 – Some evidence to support adjunctive amoxicillin and metronidazole for treating patients with aggressive periodontitis



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