Leen Vereenooghe summarises the TOP-COG study (Towards Onset Prevention of COGnitive decline in adults with Down syndrome). This pilot RCT highlights the need to educate people with learning disabilities and their carers about the importance of research participation.
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Samei Huda mulls over a recent RCT on the effects of older and newer antipsychotics on quality of life in schizophrenia. The study finds a different result to the 10-year old CUTLASS trial; namely that second generation antipsychotics may be superior to first generation antipsychotics in terms of improving quality of life for people with schizophrenia.
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Emily Stapley summarises a Mendelian randomisation study that investigates associations between the timing of menarche with depressive symptoms and depression in adolescence.
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John M Davis considers the implications of the ACTION RCT, which investigates SSRI augmentation of antipsychotics using the antidepressant Citalopram for people with schizophrenia who experience negative symptoms.
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Ioana Cristea appraises the recently published COBRA randomised controlled trial, which concludes that behavioural activation is non-inferior to cognitive behavioural therapy for depression, and may offer significant cost savings.
This blog also features a podcast interview with the lead author: Professor David Richards from Exeter University.
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Suzanne Dash considers the findings of a recent RCT of exposure-based cognitive-behavioural therapy via the internet and as bibliotherapy for somatic symptom disorder and illness anxiety disorder.
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Paul Christiansen presents the results of the EAGLES RCT into the neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patches in smokers with and without psychiatric disorders.
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Alastair Canaway summarises a trial of the clinical and cost-effectiveness of internet-based problem-solving guided self-help intervention, in comparison with enhanced usual care, for outpatients on a waiting list for face-to-face treatment for major depression.
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Murtada Alsaif summarises a recent 4-week long phase II randomised controlled trial of ITI-007 for the treatment of schizophrenia, which contains some positive results for this novel intervention.
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Dave Steele summarises a recent RCT which compares Parent-Focused Treatment and Family-Based Treatment for adolescents with Anorexia Nervosa.
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