Results: 675

For: randomised controlled trial

Mindfulness-based cognitive therapy cannot substitute maintenance antidepressants for preventing depression relapse

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Ioana Cristea takes a closer look at a recent non-inferiority RCT, which compares mindfulness-based cognitive therapy (MBCT) plus discontinued antidepressants versus MBCT and maintenance antidepressants.

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Long-term psychoanalytic psychotherapy for treatment-resistant depression

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Sarah McDonald presents the results of the Tavistock Adult Depression Study; a pragmatic RCT of long-term psychoanalytic psychotherapy for treatment-resistant depression.

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Nicotine patches, Varenicline and combination NRT: as good/bad as each other?

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Paul Christiansen considers the findings of a recent RCT, which evaluates the effects of nicotine patches versus varenicline versus combination nicotine replacement therapy on smoking cessation at 26 weeks.

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Cognitive therapies for depression in adults: let’s just stick to the facts

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Ioana Cristea reviews the NIHR-DC Highlight on cognitive therapies for depression, published online today, which summarises three NIHR-funded trials (REEACT, CoBalT and PREVENT) looking at cCBT, CBT and MBCT for depression in adults.

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Cognitive stimulation therapy for dementia

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Clarissa Giebel summarises a multicentre RCT that assesses the clinical effectiveness and cost-effectiveness of individual cognitive stimulation therapy for dementia.

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Root canal treatment – no differences between single or multiple visit approaches

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This RCT found no differences between single and multiple visit root canal treatment outcomes at 18 months Success rates for single visit treatments were 88.9% compared with 87.4% for multiple visits

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Aripiprazole for treatment-resistant depression in older adults

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Sarsha Wilson publishes her debut blog about a recent RCT on the efficacy, safety and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in later life.

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CBT plus medication for treatment-resistant depression: the CoBalT RCT long-term follow-up

In February 2016 we blogged CoBalT and concluded that CBT plus usual care (including antidepressants) is clinically and cost effective in the long-term for people whose depression has not responded to medication.

Sarah McDonald considers the findings of the CoBalT RCT long-term follow-up, which finds that CBT plus antidepressants are clinically and cost effective for treatment-resistant depression in primary care.

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A new MANTRA for treating anorexia nervosa? The MOSAIC study

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Helen Bould considers the findings of the MOSAIC RCT that compares the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with broadly defined Anorexia Nervosa.

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