Another debut blog today, this time from Suzanne Dash, who presents the results of the REEACT trial published last week in the BMJ. The study found limited uptake of computerised CBT by people with clinical depression and no benefit of free or commercially available cCBT packages over usual GP care.
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Kirsten Lawson explores the benefits of working across professional and therapeutic boundaries, highlighted beautifully by the recent COINCIDE RCT of collaborative care for patients with depression comorbid with diabetes or cardiovascular disease.
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Karina Lovell appraises the first UK RCT of computerised cognitive behavioural therapy (cCBT) for depression in children and young people, which shows a clinically meaningful improvement in depression and anxiety.
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Alex Langford reflects on the media hype surrounding a new RCT of the NAVIGATE intervention; a comprehensive, multidisciplinary, team-based treatment approach for first episode psychosis.
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Dan-Mikael Ellingsen explores the neurochemistry of placebo effects in major depression, as he reviews a recent study of the association between placebo-activated neural systems and antidepressant responses.
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In her debut blog, Jacqueline Burns considers a school-based cluster RCT, which demonstrated a small short-term improvement on oral self-care, using a social-cognitive theory based intervention.
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Simon Wessely responds to the huge amount of recent criticism that has surrounded the publication of a follow-up paper of the PACE trial into chronic fatigue syndrome. This extended blog presents the PACE trial and its main results, but also reminds us what makes a good RCT, as well as exploring how well PACE measures up.
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This trial of the effects of primer on the bracket failure rate in orthodontic patients involved 49 patients, using a cross-mouth design; and found fewer bonding failures in the non-primer group 5.5%, compared with 3.1% in primer setting and adjusted odd ratio of 1.89 (95% CI 0.97–3.68).
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Rachel Brand looks at a recent RCT which investigates the optimal duration of an early intervention in psychosis programme for young people in Hong Kong.
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This randomised trial examined the use of social media (YouTube ) for the provision of patient information to those undergoing fixed orthodontic treatment. A larger improvement in knowledge was seen in the YouTube group at 6-8 weeks.
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