Results: 1413

For: meta-analysis

Do people stop smoking if their doctor advises them to? Cochrane review says sometimes and it IS worth the effort

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As previously discussed on the Mental Elf, the rates of tobacco smoking in most developed countries are falling, helped in part by high levels of taxation and bans on smoking in public places. However, over 20% of adults in the UK continue to smoke, and this means that smoking is the greatest single cause of [read the full story…]

Moderators of outcome in late-life depression: should we be prescribing antidepressants to older people?

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Meta-analyses are an incredibly useful tool for synthesising evidence. However, such analyses typically use aggregate data, meaning the average scores or outcomes for treatment groups, which can cause problems if we’re trying to dig a little deeper into the question of ‘what works’ to answer ‘what works, and for whom?’ The ‘for whom?’ question is [read the full story…]

Atypical antipsychotics can lead to weight gain in children and adolescents, but more evidence needed about metabolic side effects

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Atypical (second-generation) antipsychotics are used to treat a variety of psychiatric conditions. Although they have fewer side effects than first-generation antipsychotics, weight gain and other metabolic problems (such as high blood pressure and diabetes) remain common side effects of taking atypical antipsychotic medication (Mind, 2012). The Mental Elf has previously blogged about a Canadian report [read the full story…]

Tricyclic antidepressants are associated with higher risk of bone fracture

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While most people would likely associate tricyclic antidepressants (TCAs) with more common adverse effects such as dry mouth, sedation and constipation, there is some evidence to suggest increased occurrence of bone fractures (Vestergaard, Rejnmark, & Mosekilde, 2006). However, the topic remains controversial and conflicting results about the association of TCAs and fracture risk abound (e.g. [read the full story…]

Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: what about the impact of gender?

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Life after cancer diagnosis and treatment is full of uncertainties for the patients and their caregivers. The possibility of cancer returning is hard to dismiss at least in the first few years after the end of treatment. Life has often changed in many imperceptible and subtle ways for people who have undergone cancer treatment, as [read the full story…]

Systematic review: which anti-psychotic medication is the best?

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Schizophrenia is considered a chronic long-term debilitating condition, affecting about 1% of the population. There has been considerable debate about which of the anti-psychotic medications are the best treatments. The debate has usually been structured around typical (older) and atypical (newer) anti-psychotic medications. The revised NICE guidelines (2009) moved towards a more neutral stance between [read the full story…]

Do interventions proven to improve cardiovascular disease outcomes work for individuals with severe mental illness?

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Individuals with severe mental illness (SMI) have shortened life expectancies compared to the general population. This is partly down to higher rates of chronic physical illness. Cardiovascular disease (CVD) is the leading cause of death among patients using mental health services. It is assumed that interventions used to reduce CVD are similarly effective in patients with [read the full story…]

New Cochrane review provides strategies for managing sexual dysfunction brought on by antidepressants

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One of the major complaints of people on antidepressant medication is the effect it has on their sex lives. It does this in three main ways – it affects sexual desire, the ability to achieve and sustain an erection in men and alters the sensation of orgasms and ejaculation. These side effects are one of [read the full story…]

The magnificent 7? Review finds that different “talking therapies” offer similar benefits to people with depression

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Scientific studies comparing treatments for depression and depressive disorders keep the mental elves very busy. Most months we are asked to blog on about 3 newly published reviews on this hot topic. The interest in research on the treatment of depression comes as no surprise, when one considers that depressive disorders affect a staggering one-fifth [read the full story…]

Cochrane review finds quetiapine is equivalent in efficacy to typical antipsychotics and possibly causes fewer side effects

Antipsychotic medication is the standard treatment for schizophrenia and psychosis in the UK.  Given that psychosis is commonly a chronic condition and therefore that medication used to treat it often needs to be taken for several years, getting the medication “right” is important. As I mentioned in my first blog post for the Mental Elf, [read the full story…]