Results: 1413

For: meta-analysis

Observational study: antidepressant suicidality warnings may be counterproductive

Warning about pills

Selective serotonin reuptake inhibitors (SSRIs) have long been suspected to – paradoxically- increase suicidal behaviour in adolescent and pediatric patients. Consequently, national watchdogs started issuing black label warnings for all SSRIs to educate physicians and patients about associated risks. While clearly curbing the amount of antidepressant prescriptions, concerns have been voiced that this step has [read the full story…]

Transcranial magnetic stimulation (rTMS) enhances response to antidepressants: a rather flawed meta-analysis

An image of a brain

It’s a well-known fact that elves are allergic to unhappiness, so the fact that there are at least 350 million sufferers of depression worldwide1 is quite a problem. That’s before we’ve even mentioned the crippling mortality, morbidity and economic impact that depression causes. The trouble is, our treatments for depression aren’t perfect. Less than a [read the full story…]

More frequent psychotherapy may lead to better depression outcomes, says new meta-analysis

Calendar

Psychological therapies such as cognitive behaviour therapy, interpersonal psychotherapy, behavioural activation, problem-solving and possibly psychodynamic therapy have been clearly shown to be effective in the treatment of adult depression. However it is not clear, how long such a therapy should last, how many sessions are optimal and what the best intensity of psychotherapy is. A [read the full story…]

Computerised CBT is effective for depression in the short-term, but new meta-analysis suggests no long-term functional improvement

Help button on a computer keyboard

Studies have demonstrated that CBT works at least as well as antidepressants at reducing depression, perhaps even better (DeRubeis et al., 1999). However, it’s difficult for people with depression to access CBT due to lengthy waiting lists. The Improving Access to Psychological Therapies (IAPT) scheme has had a major influence on waiting times for people [read the full story…]

Meta-analysis finds medium-sized deficit for IQ-change in schizophrenia patients

lightbulb brain

When Kraepelin first described the symptoms of the disorder we now call schizophrenia, he drew particular attention towards the deterioration of cognitive function he observed in his patients and named their condition “dementia praecox”. To this day, cognitive deficits are still regarded as one of the key features of schizophrenia (and related diagnoses), and it [read the full story…]

Moderate significant association found between positive parenting and outcomes for children with disabilities

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This USA based meta-analysis looked at the association between parenting and outcomes for children with developmental disabilities. The authors point out that despite there being an extensive literature supporting the positive relationship between positive parenting and child outcomes for typically developing children, there has been little work to analyse the literature specific to children with [read the full story…]

SSRIs and TCAs are equally effective at treating chronic depression, but SSRIs have fewer side effects

Tightrope walker

Major depression all too often develops a chronic course, with every episode making future relapse more likely (Gilmer et al., 2005). Dysthymic disorders represent a less severe, but more persistent form of depression lasting for at least two years. In the affective disorder spectrum, chronic forms are unsurprisingly associated with greater functional impairment and overall [read the full story…]

Can psychosocial treatments be used effectively to treat disruptive behaviour problems in young children?

Child having a tantrum

Disruptive behaviour problems (DPB) such as conduct problems or being oppositional and defiant affect a large proportion of young children. For example, one in eleven pre-schoolers may show these behaviours to a degree that would warrant a formal diagnosis of disruptive behaviour disorder. Because these early ‘externalising’ behavioural problems are stable across time, and eventually [read the full story…]

Depression increases risk of all cause mortality (not just heart disease) in diabetes

Depression is associated with mortality of all causes

This blog is coming across the woodland in stereo as the Diabetes and Mental Elf join forces. In 2011 the Diabetes Elf highlighted Depression and Diabetes: a two way street? a systematic review looking at cause and effect of diabetes and depression and the link between diabetes and cardiovascular disease is not contested. However moving forward [read the full story…]

Methadone for opioid detoxification as effective as other medications, but all have high relapse rates

Heroin addiction

Dependence on opiates (a group of drugs including heroin, morphine, and methadone) can be highly destructive for both the individual and for the people around them. Heroin addiction in particular is associated with major health risks, co-morbid mental health problems, and a wide-range of social issues. Attempting to stop opiate use leads to severe withdrawal [read the full story…]