Helen Bould summarises a meta-analysis of interventions for caregivers of someone with an eating disorder, which highlights a lack of high quality primary research.
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Helge Hasselmann highlights a recent systematic review of anti-inflammatory drugs for depression, which concludes that NSAIDs, in particular celecoxib, decreases depressive symptoms without increased risk of adverse effects. However, the meta-analysis has a number of draw-backs, which make the study findings far from convincing.
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Should all molecular research institutes looking at neurodegenerative diseases be replaced by parks, playgrounds and cycle paths? Mark Horowitz highlights a recent systematic review of modifiable risk factors associated with cognition and dementia, which suggests that from a public health perspective, there may be some sense in this idea.
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The prevalence of root caries is expected to rise and this review looked at a range of agents for non-invasive management. While 30 studies were identified they consider a large number of agents. While the review suggested that 5000ppm fluoride dentifrice was effective the number of available trials for this and the other agent was small and of limited quality.
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This review of caries excavation strategies identified 28 studies including 19 RCTs. None were considered to be at low risk of bias . The results suggest that not attempting to remove all softened or stainable dentine could reduce the risk of complications
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This review included 155 observational studies, which although of low quality consistently found caries parameters to be significantly higher in those from lower socioeconomic positions
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For his ninth Mental Elf blog, Mark Smith reports on a Cochrane systematic review of the effectiveness of short term psychodynamic therapies on common mental health disorders.
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While this new review of observational studies does suggest an increase in tooth erosion in those suffering with eating disorders concerns of the quality of the available evidence means that this is not sufficient to support a causal role for eating disorders in tooth erosion.
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Another review of failure rates of dental implants shows increased failure rates in patients with generalised aggressive periodontitis. Six studies (5 from the same research group ) involving 290 patients and 834 implants were included.
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This new review identified 22 studies but no randomised trials and found a higher dental implant failure rate in periodontally compromised patients than health ones. However concerns over study quality means the findings should be interpreted with caution.
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