Results: 675

For: randomised controlled trial

Extended therapy with varenicline reduces rates of smoking relapse in people with serious mental health issues

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People with serious mental health issues such as schizophrenia have higher rates of cigarette smoking than the general population, with estimates suggesting more than 50% are current smokers. When people in this population do manage to quit during treatment we then see particularly high rates of relapse after treatment ends. A new randomised control trial (Evins [read the full story…]

Combination of treatments may improve smoking cessation

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Smoking is a major cause of morbidity and mortality across the world and accounts for over 60% of deaths in people who do smoke. The World Health Organisation estimates that tobacco kills almost 6 million people per year, with 5 million as a result of direct tobacco use. Innovative treatment approaches aimed at improving smoking [read the full story…]

Trial found similar success rates for partial pulpotomies in permanent molars using mineral trioxide aggregate and calcium hydroxide

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The aim of this study was to compare the outcome of partial pulpotomies in cariously exposed pulps of young permanent molars using mineral trioxide aggregate (MTA) and calcium hydroxide in a randomized controlled trial. Eighty-four teeth in 80 patients (aged 7-10yrs) having one or two first permanent molars with deep occlusal carious lesions that resulted [read the full story…]

Study suggests that dentifrices containing 1.5% arginine, an insoluble calcium compound provides additional benefit to fluoridated toothpastes

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Cochrane reviews have clearly documented the anti-caries benefits of fluoridated toothpastes (Marhino et al 2003, Walsh et al 2010). New agents to improve caries prevention would assist efforts to reduce the impact of caries, particularly on children. The aim of this study was to investigate the efficacy of two dentifrices containing 1.5% arginine, an insoluble [read the full story…]

Pilot study suggests that CBT may be a viable alternative to antipsychotics for people with schizophrenia, or does it?

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People with schizophrenia stop taking their antipsychotics for a wide range of reasons (e.g. debilitating side effects or a belief that they will not help them), but when they do health professionals often find it extremely difficult to care for these patients, because the alternative treatment options available to them are very limited. Of course, [read the full story…]

Fluoride varnish in pre-school children

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The effectiveness of fluoride varnishes for caries prevention for children and adolescents is well established with the recent update of the Cochrane review (Marinho et al 2013) estimating the pooled preventive fraction of 43% (95% CI 30-75%) for permanent teeth  and 37% (95% CI 24-51%) for primary teeth.  However although 22 trails were included there [read the full story…]

On-demand analgesic use following root canal treatment resulted in similar pain relief but reduced consumption compared with regular prescription

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The management of pre- and post-operative pain is a key component of endodontic treatment with studies reporting that the incidence of post operative pain (flare-up) ranges from  3-58%.   Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medication used for managing pain after root canal treatment (RoCT). The aim of this study was to compare the [read the full story…]

Targeted mental health support can improve borderline-clinical behavioural problems in children

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The statistic that one in four adults in Britain will experience a mental health problem in any given year is well known (if still debated), but a recent report by the Children and Young People’s Mental Health Coalition revealed a lack of such statistics for children. The report also highlighted that Office for National Statistics [read the full story…]

Focal psychodynamic therapy or CBT vs optimised treatment as usual in outpatients with anorexia

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Anorexia nervosa has long been known to have a poor prognosis and few effective treatments are available (Kaplan and Garfinkel, 1999). Research in this area is limited, particularly in regards to evidence-based guidance.  The NICE eating disorders guidance (2004) is in need of an update, although there is a more recently produced care pathway. Other [read the full story…]

Long term maintenance treatment with antipsychotics: a cautionary note from recent research

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The support of individuals with experience of psychosis is complex and relies on a combination of psychopharmacology (antipsychotic drugs), psychological therapies and social interventions. Antipsychotics will often be the first line treatment offered, with the intention of reducing psychotic symptom burden. Following the resolution of immediate symptoms the role of antipsychotics becomes less clear; should [read the full story…]