Results: 675

For: randomised controlled trial

RCT compares two different versions of enhanced cognitive behavioural therapy for anorexia nervosa in an inpatient setting

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A general misconception about anorexia is that it’s just about eating and ‘being thin’, but it’s more complex than that. The illness affects multiple aspects of a person’s life, and often goes hand in hand with other psychological issues such as low mood, or excessive worry. In addition, the jury is still out on the exact [read the full story…]

Use of higher concentration fluoride toothpaste (5000 ppm F) had a beneficial effect on root caries

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The aim of this clinical trial was to test the effectiveness of high-fluoride toothpaste (5000 ppm F) on root caries lesions in adults and to test the hypothesis that high concentration fluoride tooth- paste would effectively improve the surface hard- ness in root caries lesions in adult patients. Adult patients (18-75yrs) with 10 or more [read the full story…]

Cognitive therapy is a non-stigmatising intervention for people at risk of psychosis

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Criteria to identify subgroups experiencing an at-risk mental state (ARMS) have been developed and are widely adopted internationally, but this has fueled recent debates about unintended stigmatising consequences of identifying and providing treatment to people at risk of psychosis. While the Early Detection and Intervention Evaluation 2 (EDIE-2) trial has shown that cognitive therapy (CT) [read the full story…]

Trial suggests that post extraction use of warm saline mouth rinse reduces complications

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The use of warm salt water mouthrinses as part of a post extraction regimen is a commonly taught, yet as the authors of this trial found there seems to be little objective evidence for its effectiveness.  The aim of this study was to determine the beneficial effect of different warm saline rinse regimens on the [read the full story…]

Study suggests use of resin-bonded bridgework more cost effective than removable dental prostheses in older partially dentate patients

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The aim of this study was to assess the cost-effectiveness analysis of two different tooth replacement strategies for partially dentate older patients; partial removable dental prostheses (RDP) and functionally orientated treatment based on the shortened dental arch concept (SDA). Partially dentate patients aged 65 years and older seeking replacement of missing natural teeth, had a [read the full story…]

Counselling is as effective as CBT for depression, according to a reanalysis of RCT data

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In recent years, cognitive-behavioural therapy (CBT) has become the most widely delivered therapy for depression within the NHS.  CBT interventions are recommended by NICE for people with mild, moderate and severe depression. By contrast, recent NICE guidelines recommend counselling only for people with persistent subthreshold depressive symptoms or mild to moderate depression who decline another [read the full story…]

D-cycloserine does not improve CBT for social anxiety disorder, but may accelerate early treatment gains

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Clinical trials in the field of social anxiety to date have primarily focussed on the effect of either anxiolytic medication or cognitive behavioural therapy (CBT). At best these trials have demonstrated only moderate efficacy for either treatment independently (Davidson et al, 2004; Clark et al, 2003; Heimberg et al, 1998; Stein et al, 1998), and [read the full story…]

Largest RCT so far suggests that ketamine may be useful in the acute treatment of refractory depression

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Major depression is a serious mental illness that often does not respond to mainstream drug treatment (antidepressants). In addition, there is usually a delay of 2-6 weeks before mood improves significantly. In situations like this, when at least two conventional antidepressants have been tried without success, depression is considered treatment-resistant. While multiple different strategies to [read the full story…]

Is gabapentin a promising drug for the treatment of alcohol dependence?

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Alcohol misuse is responsible for about 4% of all deaths annually, and in the UK it costs the NHS more than £3 billion per year.  A number of medications are currently licensed for the treatment of alcohol dependence. Unfortunately the medications don’t work for everyone and in the USA at least, fewer than 10% of [read the full story…]

Limited study suggests that use of semi-rigid plates and screws reduce mandibular fracture treatment costs

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Fractures of the mandible are a common occurrence.  Two approaches to treatment of mandibular fractures are; rigid fixation using large titanium plates and bicortical screws that function in a load-bearing manner using Arbeitsge-menschaft fur Osteosynthesefragen (AO) principles or semi-rigid fixation using small titanium plates and monocortical screws that function in a load-sharing manner placed according [read the full story…]