This review of the efficacy of a chlorhexidine mouthwash containing sodium fluoride compared to a chlorhexidine mouthwash alone includes 10 small short term studies that suggests the findings are similar for both preparations.
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Michelle Eskinazi and Clara Belessiotis write their debut elf blog on a recent meta-analysis of smartphone‐based mental health interventions for depression, which concludes that there is a possibly promising role for apps in the prevention and treatment of sub-clinical, mild and moderate depressive symptoms.
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27 RCTs were identified for this Cochrane review update early v late orthodontic treatment for class II div 1 malocclusion. The main advantage of early treatment was a reduction of incisal trauma.
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This review of a possible association between oral Candida albicans and early childhood caries (ECC) included 15 cross-sectional studies.The prevalence of C. albicans in children with ECC was found to be significantly higher than in caries-free children.
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29 mainly retrospective studies were included in this review of conservative management approaches for odontogenic keratocysts. While the findings suggest use of decompression followed by enucleation data for recurrence were lower than those found in previous reviews of the topic. High quality prospective studies are needed.
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Students and Teachers from the King’s College London PNoMH Distance Learning MSc summarise a major new meta-analysis that brings together the last 60 years of placebo-controlled antipsychotic drug trials in acute schizophrenia.
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52 studies were identified for this review of the effect of extraction or non-extraction fixed orthodontic treatment of soft tissue profiles . However they were mainly poor quality retrospective studies providing very low quality evidence suggesting that tooth extractions might be associated with differences in the soft tissue profile compared to non-extraction treatment.
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Mark Edwards considers the findings of a new meta-analysis of case-control studies, which looks at the relationship between stressful life events, neglect and abuse with functional neurological disorder.
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André Tomlin reports on a new network meta-analysis that brings together the best available evidence comparing the efficacy and acceptability of 21 antidepressants for the acute treatment of adults with major depressive disorder.
This groundbreaking review of 522 trials is the largest ever meta-analysis in psychiatry, and finds that antidepressants are more effective than placebo for short-term treatment of acute depression in adults.
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This review of non-pharmacological intervention to reduce mental distress, pain, and analgesic use in adults undergoing dental treatment included 29 RCTs. The findings suggest positive benefits for the interventions examined with no significant differences between the various interventions.
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