Time to stop prescribing antidepressants to young people with depression?

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Andrew Shepherd considers the implications of a recent network meta-analysis of the efficacy and tolerability of antidepressants for children and adolescents with depression.

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Antidepressants and psychotherapy for OCD in adults: network meta-analysis

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Alan Underwood summarises a recent network meta-analysis of medication and talking treatments for OCD (obsessive-compulsive disorder) in adults.

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Pharmacotherapy for smoking cessation in severe mental illness

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Andrew Jones reports on a recent systematic review and network meta-analysis of the efficacy and tolerability of pharmacotherapy for smoking cessation in severe mental illness, which finds a promising but low quality result for bupropion and varenicline.

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Antipsychotics for treatment-resistant schizophrenia

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Murtada Alsaif summarises a recent network meta-analysis, which looks at the efficacy, acceptability and tolerability of antipsychotics for treatment-resistant schizophrenia.

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IPT and CBT best for depression in children and young people, says network meta-analysis

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Laura Hemming summarises a recent network meta-analysis of psychotherapies for depression in children and young people, which finds that Interpersonal Psychotherapy (IPT) and Cognitive Behavioural Therapy (CBT) were significantly more efficacious than other psychotherapies at post-treatment and follow-up.

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Psychotherapies for depression in children and young people

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Shirley Reynolds considers the findings of a recent network meta-analysis, which investigates the comparative efficacy and acceptability of psychotherapies for depression in children and adolescents.

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Caries: micro- and minimally invasive treatments for pit-and-fissure lesions

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This network meta-analysis included 14 studies (10 RCTs) and suggests that minimally invasive strategies would rank first followed by micro invasive approaches to pit and fissure caries. However, for some comparisons only a few studies are available and then are generally small and with short follow up periods.

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Is electrical stimulation effective for pain relief in OA knee?

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Are you standing comfortably? It’s time for Tracey Howe to tell us about the efficacy of different electrical stimulation therapies on pain relief of patients with knee osteoarthritis.

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Review suggests that mineral trioxide aggregate had best clinical and radiographic outcomes at 9-12 months for primary molar pulpotomy

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When I was training formocresol was the standard dressing for primary teeth following pulpotomy . However, it  use is now questionable because of potential adverse effects such as potential carcinogenicity, mutagenicity, and cytotoxicity.  Consequently a range of other materials have been investigated,  ferric sulphate, gluatraldehyde preparations , mineral trioxide aggregate (MTA), electrosurgery, calcium hydroxide, and laser [read the full story…]

Combination therapies performed better than single ones for treating periodontal bony defects, but additional benefits were small

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A range of regenerative treatments have been used for the  treatment of periodontal infrabony defects. Guided tissue regeneration (GTR) and enamel matrix derivatives (EMD) are two popular treatment and they have both been used in combination with other treatment.   This network meta-analysis was conducted to assess the potential effects of the various combinations. Unlike a [read the full story…]