Results: 40

For: oral cancer

Oral cancer- monoclonal antibodies combined with standard treatment may improve outcomes

shutterstock_54791728 - Cancer word cloud

12 trials were included in this Cochrane review of molecularly targeted therapies and immunotherapies as adjuncts to standard treatments for oral cancer. Moderate evidence was found that standard therapy plus epidermal growth factor receptor monoclonal antibody (EGFR mAb) reduced mortality and locoregional failures.

[read the full story...]

Oral Cancer – DNA-image cytometry may have promise for early detection

herpetic ulcer on tongue

This diagnostic review compared two computer aided adjunctive tests for oral cancer. Oral CDX and DNA-image cytometry. The results suggest that DNA-image cytometry has a highly significant potential over OralCDx brush biopsy as an accurate and simple diagnostic tool for clinically suspected oral precancer and oral cancer.

[read the full story...]

Oral leukoplakia: malignant transformation rate highly variable

herpetic ulcer on tongue

This review of the malignant transformation rate of oral leukoplakia included 24 studies, the majority of which were retrospective. The range of malignant transformation was between 0.13% and 34.0%. The quality of the available data was limited and there is a need for higher quality well-reported studies.

[read the full story...]

Oral Cancer diagnosis: biopsy and histology still best method

herpetic ulcer on tongue

This Cochrane review of adjunctive diagnostic tests for oral cancer included 41 studies assessing vital staining, cytology, and light-based tests. The available studies were of poor quality detection with none of the tests being considered as a replacement for the currently used standard of a scalpel biopsy and histological assessment.

[read the full story...]

Photodynamic therapy: review finds insufficient evidence of its effectiveness for oral premalignant lesions

iStock_000001604217XSmall dental laser

This review of photodynamic therapy (PDT) for oral premalignant lesions only identified a small number of poor quality studies that provide insufficient evidence for the effectiveness of PDT for the management of oral premalignant lesions.

[read the full story...]

Alcohol consumption increased oral cancer risk

shutterstock_59265916

This new review investigated the effect of alcohol on 23 cancer types. They included 572 case-control and cohort studies and using meta-analysis and a dose–response meta-regression model found relative risks for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer.

[read the full story...]

Oral cancer detection: Limited evidence for use of chemiluminescence and autofluorescent imaging devices in primary care

iStock_000001604217XSmall dental laser

Early detection of oral cancer improves prognosis so methods to improve diagnosis are welcome. The review we look at today looks at two light-based systems: chemiluminescence or autofluorescence. 25 studies were included and they are well summarised but few were tested in primary care. Neither system provided much improvement on the level of sensitivity and specificity achieved by conventional oral examination. Therefore it is suggested that these tools are better suited to specialist clinics in which there is a higher prevalence of disease and where experienced clinicians may better discriminate between benign and malignant lesions.

[read the full story...]

Oral examination to detect potentially malignant disorders and mouth cancer

shutterstock_45382273

November is Mouth Cancer Awareness month here in the UK and around 6,500 cases are diagnosed a year. Mouth cancer is the 6th commonest cancer worldwide.  In India, Sir Lanka and Pakistan it is the most common cancer for men and is responsible for 30% of all new cancer cases. Tobacco use, alcohol consumption, betel [read the full story…]

Oral cancer support needs are highly subjective and varied in severity across the cancer continuum

shutterstock_17409700

Worldwide oral and oropharyngeal cancer is the 6th most common cancer. Treatment often affects the individuals’ ability to eat, speak and interact with others and so is associated with significant physical and psychological burdens.  This review aimed to describe the quality of life (QoL) outcomes and support needs in patients with oral cancer along the [read the full story…]

New Cochrane Protocols February 2013

shutterstock_74352844

There are three new protocols on the February issue of the Cochrane Library The first protocol Carrasco-Labra A, Brignardello-Petersen R, Yanine N, Araya I, Rada G, Chadwick RG. Professionally-applied chemically-induced whitening of teeth in adults (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD010379. DOI: 10.1002/14651858.CD010379.  aims to assess the effects of [read the full story…]