Samei Huda mulls over a recent RCT on the effects of older and newer antipsychotics on quality of life in schizophrenia. The study finds a different result to the 10-year old CUTLASS trial; namely that second generation antipsychotics may be superior to first generation antipsychotics in terms of improving quality of life for people with schizophrenia.
[read the full story...]
John M Davis considers the implications of the ACTION RCT, which investigates SSRI augmentation of antipsychotics using the antidepressant Citalopram for people with schizophrenia who experience negative symptoms.
[read the full story...]
Chris Pell considers a recent US study of the relationship between clerical burden and e-health systems with doctor burnout and professional satisfaction.
[read the full story...]
Ioana Cristea appraises the recently published COBRA randomised controlled trial, which concludes that behavioural activation is non-inferior to cognitive behavioural therapy for depression, and may offer significant cost savings.
This blog also features a podcast interview with the lead author: Professor David Richards from Exeter University.
[read the full story...]
Suzanne Dash considers the findings of a recent RCT of exposure-based cognitive-behavioural therapy via the internet and as bibliotherapy for somatic symptom disorder and illness anxiety disorder.
[read the full story...]
Lucas Shelemy on a recent randomised longitudinal study that explores the effect of antidepressant treatment on cognitive impairments associated with depression.
[read the full story...]
Michael Ostacher provides a robust appraisal of a recent UK cohort study that suggests bipolar disorder patients taking lithium had reduced self-harm and unintentional injury rates, when compared with patients taking valproate, olanzapine or quetiapine.
[read the full story...]
Alex Langford explores the emerging findings from a recent meta-analysis looking at the efficacy and safety of antidepressants added to antipsychotics for people with schizophrenia and schizophrenia-like psychosis.
[read the full story...]
Stanley Kutcher and Yifeng Wei provide an in-depth analysis of a recent systematic review of suicide prevention strategies.
[read the full story...]
This review of antibiotic prophylaxis for the removal of third molars included 22 RCTs and suggest that antibiotic use lowered the infection risk by 60%. The number pf patients needed to treat to prevent one infection was 14 (95%CI;11-19).
[read the full story...]
