Thalia Eley and Gerome Breen explore a new systematic meta-review of predictors of antidepressant treatment outcome in depression, which looks at clinical and demographic variables, but also biomarkers including both genetic and neuroimaging data.
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10 studies were included in this review of the effectiveness of minimally invasive repair or replacement of dental restorations. The reviewers suggest that seal and refurbishment techniques did not present a significant difference in clinical longevity in comparison to the replacement technique in permanent teeth. However, both the amount and the quality of the available evidence is limited.
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36 studies were included in this review of treatment options for xerostomia, hyposalivation and quality of life in patients with Sjögren’s syndrome provinding evidence to support pilocarpine use. However the number of studies were limited and adverse effects were common.
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Just two RCTs were identified for this Cochrane review of work-related musculoskeletal disorders in dental care providers providing very-low quality evidence for physical ergonomic interventions.
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15 studies were included in this review of early orthodontic management and orofacial muscle training protocols in the developing dentition. All the included studies were at high risk of bias so high-quality evidence for early orthodontic management and myofunctional treatment in the developing dentition is lacking.
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Caroline Struthers considers a systematic review about the impacts of older people’s patient and public involvement in health and social care research.
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Joseph Hayes and Sameer Jauhar set the record straight on antidepressant withdrawal. They show how the recent review by Davies and Read is seriously flawed and does not accurately portray the data. They conclude that we urgently need clearer evidence on the incidence, severity and duration of any symptoms related to antidepressant withdrawal.
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6 RCTs were included in this Cochrane review of attachment systems for implant overdentures. The included studies provide insufficient evidence of relative effectiveness of prosthodontic success, prosthodontic maintenance, patient satisfaction, patient preference or costs.
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This Cochrane review of the efficacy of different root coverage procedures for gingival recession included 48 RCTs describing a range of procedures. Most procedures led to a reduction in gingival recession.
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Simon Brett summarises a robust systematic review that looks at the effectiveness of physical activity as a treatment for depression in adolescents and young adults.
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