This Cochrane review was seeking to identify RCTs of interventions for the management of external root resorption in permanent teeth. No published trials were identified, so clinicians must decide on the most appropriate means of managing this condition according to their clinical experience with regard to patient-related factors.
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Thirteen studies were included in this review of medication related osteonecrosis of the jaw. The majority were case series ( 9) with the risk of osteonecrosis after tooth extraction being higher in those taking IV bisphosphonates ( 3.2% (95% CI: 1.7–4.7%) than those on oral bisphosphonates 0.15% (95% CI: 0.0–0.36%).
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NICE has completed a review of its 2008 guidance on antimicrobial prophylaxis against infective endocarditis following the publication of a recent study. NICE found no need to change any of its existing guidance.
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The update of a 2007 Cochrane review of parasympathomimetic drugs for dry mouth after radiotherapy did not identify an new studies. The 3 RCTs identified in the previous version provide limited evidence to support the use of pilocarpine hydrochloride in the treatment of radiation-induced xerostomia.
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This small randomised trial found improvements in quality of life for patients with oral lichen planus at both 4 weeks and 20 weeks following implementation of a structured oral hygiene instruction.
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Ten small RCTs were included in this review. They suggest that topical tacrolimus is more efficacious than clobetasol for oral lichen planus.
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10 studies involving 746 adult patients were included in this review comparing articaine and lidocaine in patients with symptomatic irreversible pulpitis. Articaine was as effective as lidocaine and provided better supplementary infiltration after mandibular block but no other advantages.
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This small trial suggests that that while the diode laser treatment was marginally quicker than the traditional scalpel removal of fibrous hyperplasia, it required fewer analgesics and no sutures. However, there was more swelling, and wound healing was longer.
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14 studies were included in this review of the impact of oral potentially malignant disorders of the quality of life. However, they were mainly focused on oral lichen planus, so they provide little evidence for the impact of the wide range of OPMDs on the quality of life.
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This review of the malignant transformation rate of oral leukoplakia included 24 studies, the majority of which were retrospective. The range of malignant transformation was between 0.13% and 34.0%. The quality of the available data was limited and there is a need for higher quality well-reported studies.
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