Results: 177

For: oral medicine and pathology

Articaine: Safety and efficacy compared to lidocaine

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This review assessing the safety and efficacy of articaine for routine dental treatment compared to lidocaine included 12 RCTs involving a total of 919 patients. The findings indicate that articaine is is a safe and efficacious local anaesthetic for all routine dental procedures.

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Topical anaesthesia: Does it reduce pain perception of local anaesthetic injections?

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This review of the effectiveness of topical anaesthesia in in reducing pain during local anaesthetic injections for dental procedures included 22 RCTs. Statistically significant differences were seen during needle puncture with topical anaesthetic use in the maxilla and palate but not the mandible.

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Intraoral stents to reduce oral toxicity of radiotherapy

Varian TruBeam Linear Accelerator, Rathiotherapy

This review assessing the effectiveness of intraoral stents in reducing toxicities in oral cavity induced by radiotherapy in head and neck region included 7 small studies. While the analysis suggests a beneficial effect from the use of intraoral stents the included studies only provide verylow certainty evidence so further high-quality RCTs are needed.

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Denture stomatitis: Are natural products effective?

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This review comparing topical natural substances with conventional antifungals in the treatment of denture stomatitis included 17 studies 14 of which were RCTs. A wider range of natural products were tested and showed similar efficacy to antifungals however, almost all the studies were at high risk of bias so the certainty of the evidence is very low.

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Oral proliferative verrucous leukoplakia and the rate of malignant transformation

Leukoplakia , Verrucous

This review of the evidence on the malignant transformation of oral proliferative verrucous leukoplakia included 17 mainly retrospective observational studies. The overall estimate for malignant transformation was 43.87% (95% CI; 31.93 to 56.13) but only 4 studies were at low risk of bias.

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Head and neck soft tissue sarcomas

Sarcoma. fibrosarcoma

This review of the distribution of histological subtypes, treatment and overall survival (OS) rates of head and neck sacomas included 8 studies from 6 countries. Meta-analysis (5 studies) found the 5-year OS = 74%(95%CI; 63 to 84%)

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Diagnostic accuracy of salvia tests for SARS-CoV-2

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This review of the use and diagnostic accuracy of saliva tests for the detection of SARS-CoV-2 included 16 studies. THe findings suggests good diagnostic accuracy but furteher research is needed to determine confounding factors such as method and time of sample collection, transport medium, storage etc. prior to population testing.

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Prevalence of burning mouth syndrome

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This review evaluating the worldwide prevalence and epidemiology profile of burning mouth syndrome included 18 studies. Population based studies suggest an overall prevalence of 1.73% and clinically-based studies a 7.72% prevalence.

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Oral leukoplakia and rate of malignant transformation

Leukoplakia

This update of an earlier review of the malignant transformation rate of oral leukoplakia included 24 retrospective studies. The pooled proportion of malignant transformation was 9.8% (95%CI; 7.9 to 11.7%)

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