Joe Judge appraises a recent systematic review and meta-analysis looking at the duration of untreated psychosis as a predictor of long-term outcomes in schizophrenia.
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Olivia Maynard summarises a systematic review of smoking cessation interventions in the emergency setting, which highlights the poor quality and heterogenous nature of the published trials in this field.
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Nikki Newhouse summarises a recent US health technology assessment of antidepressants for depression in pregnancy and the postpartum period, which concludes that the evidence remains inconclusive about the benefits and harms of antidepressants for depression in pregnancy.
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Helge Hasselman summarises a Cochrane review of tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents, which finds low quality evidence and no justification for prescribing these drugs in this group of patients.
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Liz Hughes summarises two recent studies (1 systematic review and 1 RCT) that both investigate brief interventions for reducing the use of benzodiazepines in primary care.
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Laurence Palfreyman summarises 3 recent Cochrane reviews, which investigate high-potency versus low-potency first-generation antipsychotic drugs for schizophrenia. The reviews find little difference in efficacy between the high-potency antipsychotics Trifluoperazine, Haloperidol, Fluphenazine, and low-potency typical antipsychotics.
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Andrés Fonseca appraises a new systematic review of interventions for treatment-resistant anxiety in older people, which finds a disconcerting lack of evidence to help him support the many older patients he sees who are affected by anxiety disorders.
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Chris Sampson reports on a recent systematic review and critical appraisal of economic evaluations in bipolar disorder. He finds that there’s a pressing need for new studies, especially discrete event simulations.
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Andrew Jones and Chris Sampson report on a systematic review and economic evaluation of cytisine and varenicline for smoking cessation, which finds that both drugs are clinically effective compared with placebo.
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Helen Bould summarises a recent review that maps the evidence for the prevention and treatment of eating disorders in young people. Her conclusion? A call to arms for more better quality research to help people affected by these serious illnesses.
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