Negative core beliefs like “I’m worthless” or “people can’t be trusted” are linked to hallucinations, paranoia, and suicidality. This new systematic review shows how deep-rooted schemas shape psychosis, and what this means for psychological therapies.
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Psychiatric disorders are highly heritable, but are the genes we identify in GWAS the same ones our medications target? This new study digs into the overlap and raises questions about how we develop treatments.
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Emotional abuse in childhood was linked to a more than 3.5x greater chance of developing psychosis later in life. This comprehensive new meta-analysis explores the role of early trauma, sex differences, and symptom onset timing in psychosis risk.
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Rena Gatzounis blogs about a systematic review and meta-analysis investigating the effectiveness of immersive virtual reality treatments for mental health disorders.
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KCL MSc student Geetika Sharma reviews a study that looks at the contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe.
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Dr Fabiana Corsi-Zuelli discusses the differences in immune cell counts in patients with schizophrenia compared to controls; highlighting a recent meta-analysis by Dudeck et al. (2025) that reinforces the growing consensus that immune dysfunction plays a role in schizophrenia.
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Eleanor Dawkins explores a new review and meta-analysis suggesting that cognitive impairment is linked with anticholinergic medication in psychosis, providing grounds for more careful monitoring and review of medications.
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Sueda Coskun reflects on a recent case control study with data from five European countries, which suggests that migration during adolescence may be a particular risk factor for developing psychosis.
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Mary Butler explores a recent randomised controlled trial of probiotic formulations for patients with bipolar disorder or schizophrenia spectrum disorder.
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Emiliana Tonini looks at how sleep is recorded and treated in people with serious mental illness—and how it affects their engagement with services. The study finds that sleep is rarely part of routine clinical assessment, and recommended sleep treatments are hardly ever used.
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