Cannabis legalisation: what can we learn about psychosis risk from the great Canadian (quasi) experiment?

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What happens to psychosis risk when cannabis becomes easier to access? According to this Canadian study, the risk goes up. Shuichi Suetani explores what we can learn from one of the countries leading the way in drug policy reform.

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Continuing antipsychotic medication during pregnancy associated with reduced risk of schizophrenia relapse

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Shuichi Suetani and Sarah Thomas highlight new research from Korea which suggests that antipsychotic medications do seem to help reduce the relapse of schizophrenia in pregnant women.

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Alternatives to medication for ‘treatment-resistant schizophrenia’

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Kalya Win Aung, Angela Kibia and Dorothy Williams consider a systematic review and network meta-analysis published by the Lancet Psychiatry on psychological and psychosocial interventions for treatment-resistant schizophrenia.

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HRT associated with reduced risk of psychosis relapse in middle-age women

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Laura Naysmith summarises a study of menopausal hormone therapy (also known as HRT), which suggests the treatment is linked with reduce the risk of psychosis relapse in menopausal women.

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Omega-3 supplements for the prevention of psychosis: another trial shows no benefit, so is it time to move on?

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David Mongan reports on a recent trial of omega-3 supplementation for the prevention of psychosis in people at ultra-high risk, which finds no evidence of a positive effect. He reflects on these findings and considers what’s next for the field.

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The role of the gut microbiome in treatment-resistant schizophrenia

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Nuala Murray explores a recent Australian case-control study that looks at the associations between changes in gut microbiota and schizophrenia diagnosis, treatment resistance, and clozapine response.

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The many faces of mental disorders

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Yuri Milaneschi discusses new research on the structure and presentation of mental health disorders, which suggests that although there are many different faces of major mental disorders, some of these faces are far more common than others.

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Childhood neglect: the neglected trauma? 

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Dhea Bengardi summarises a systematic review exploring the prevalence of different types of neglect across a wide variety of mental health conditions.

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KarXT: an innovative and promising treatment for schizophrenia

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Nicola Rizzo Pesci and Andrea Cipriani summarise findings from the EMERGENT-2 trial spotlighting a promising new drug treatment for schizophrenia.

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