Do people stop smoking if their doctor advises them to? Cochrane review says sometimes and it IS worth the effort

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As previously discussed on the Mental Elf, the rates of tobacco smoking in most developed countries are falling, helped in part by high levels of taxation and bans on smoking in public places. However, over 20% of adults in the UK continue to smoke, and this means that smoking is the greatest single cause of [read the full story…]

Moderators of outcome in late-life depression: should we be prescribing antidepressants to older people?

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Meta-analyses are an incredibly useful tool for synthesising evidence. However, such analyses typically use aggregate data, meaning the average scores or outcomes for treatment groups, which can cause problems if we’re trying to dig a little deeper into the question of ‘what works’ to answer ‘what works, and for whom?’ The ‘for whom?’ question is [read the full story…]

Atypical antipsychotics can lead to weight gain in children and adolescents, but more evidence needed about metabolic side effects

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Atypical (second-generation) antipsychotics are used to treat a variety of psychiatric conditions. Although they have fewer side effects than first-generation antipsychotics, weight gain and other metabolic problems (such as high blood pressure and diabetes) remain common side effects of taking atypical antipsychotic medication (Mind, 2012). The Mental Elf has previously blogged about a Canadian report [read the full story…]

Tricyclic antidepressants are associated with higher risk of bone fracture

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While most people would likely associate tricyclic antidepressants (TCAs) with more common adverse effects such as dry mouth, sedation and constipation, there is some evidence to suggest increased occurrence of bone fractures (Vestergaard, Rejnmark, & Mosekilde, 2006). However, the topic remains controversial and conflicting results about the association of TCAs and fracture risk abound (e.g. [read the full story…]

Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: what about the impact of gender?

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Life after cancer diagnosis and treatment is full of uncertainties for the patients and their caregivers. The possibility of cancer returning is hard to dismiss at least in the first few years after the end of treatment. Life has often changed in many imperceptible and subtle ways for people who have undergone cancer treatment, as [read the full story…]

Meta analysis of antidepressants vs talking therapies: another example of ‘All Must Have Prizes’?

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Patients presenting to their GP with a mental health problem are likely to be offered medication, in the form of antidepressants, and/or a ‘talking therapy’, such as counselling or CBT. This is because we know that both those broad categories of treatments (drugs and psychological therapies) are effective in reducing symptoms. However, it’s less clear [read the full story…]

Systematic review finds that tricyclics do not benefit children with depression

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Clinical depression is one of the most common mental health problems occurring in children and adolescents. It is often accompanied or followed by additional negative outcomes, including social and academic problems, anxiety and substance use. Many depressed adolescents continue to have recurring problems throughout adulthood. A variety of antidepressant drugs, such as tricyclics and selective [read the full story…]

The magnificent 7? Review finds that different “talking therapies” offer similar benefits to people with depression

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Scientific studies comparing treatments for depression and depressive disorders keep the mental elves very busy. Most months we are asked to blog on about 3 newly published reviews on this hot topic. The interest in research on the treatment of depression comes as no surprise, when one considers that depressive disorders affect a staggering one-fifth [read the full story…]

More frequent psychotherapy may lead to better depression outcomes, says new meta-analysis

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Psychological therapies such as cognitive behaviour therapy, interpersonal psychotherapy, behavioural activation, problem-solving and possibly psychodynamic therapy have been clearly shown to be effective in the treatment of adult depression. However it is not clear, how long such a therapy should last, how many sessions are optimal and what the best intensity of psychotherapy is. A [read the full story…]

Computerised CBT is effective for depression in the short-term, but new meta-analysis suggests no long-term functional improvement

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Studies have demonstrated that CBT works at least as well as antidepressants at reducing depression, perhaps even better (DeRubeis et al., 1999). However, it’s difficult for people with depression to access CBT due to lengthy waiting lists. The Improving Access to Psychological Therapies (IAPT) scheme has had a major influence on waiting times for people [read the full story…]