A large Australian study suggests that atypical depression is genetically, metabolically and clinically distinct, with poorer response to SSRIs and SNRIs.
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The EPISODE trial of psychedelic-assisted therapy for ‘treatment-resistant depression’ finds only modest effects, with a few clear responders, but lingering methodological questions.
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A new meta-analysis from Toutountzidis and colleagues finds trauma-focused therapies meaningfully reduce delusions in psychosis, but offer limited benefit for hallucinations. Younger people gain most.
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We have the evidence that lifestyle interventions work. Now what? The third Lancet Psychiatry Commission focuses on the messy business of implementation.
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A single dose of tocilizumab cleared inflammation in depressed patients, but did it ease their symptoms? A proof-of-concept RCT with cautious promise.
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Mental health awareness campaigns have reduced stigma and encouraged help-seeking, but a new review asks whether they also have unintended psychological costs such as inflating distress, driving self-diagnosis, and overwhelming services.
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A new study uses AI on brain scans to predict depression. The findings are modest, but the implications go beyond the hospital.
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A new umbrella review shows in-person social engagement reduces depression, especially for older adults and people most at risk of isolation.
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Coroners have been raising concerns about child suicides for years. The first analysis to synthesise these reports reveals how governance failures, communication breakdowns, and a lack of autism-specific support have repeatedly contributed to preventable deaths.
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Up to 80% of people with personality disorder report neglect or abuse. So why aren’t we offering them trauma-focused therapy? A new trial has some answers.
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