This review of the efficacy of interdental cleaning devices (ICDs) used with active substances, as adjuncts to toothbrushing included 7 RCTs. However, none of the available studies was at low risk of bias and all were small. While the findings suggest s benefit from using ICDs with active substances the evidence is of very low certainty so additional high qiality well reported trials are needed.
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Rosalind McAlpine and Karel Kieslich summarise a recent systematic review which focuses on the rapid anti-suicidal ideation effect of ketamine.
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This review of the efficacy of fluoride-free nano-hydroxyapatite agents (nHA) to enhance remineralisation or hamper demineralisation of enamel caries included 10 small studies. 5 studies were in-vivo and 5 in-situ but they were of short duration with 7 being at high risk of bias so provide very low certainty evidence. Additional high quality well reported studies are needed to assess nHA.
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Tessa Reardon summarises a systematic review, which reports on the specific clinical and psychological factors that predict persistent anxiety disorders.
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This review of whether ultrasonic irrigation results in less postoperative root canal treatment pain than conventional irrigation included 6 RCTs. The suggests less pain with ultrasonic irrigation for the first 48 hours but no difference at 72 hours.
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This review of the performance (retention/fracture) of bulk-fill and incremental filled composite restorations place in the posterior teeth of adult patients included 14 RCTs. Only 4 of the studies were at low risk of bias and while no difference was shown between the two approaches but the number of failures was small small.
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This Cochrane review of the effects of sealants compared to no sealant or a different sealant in preventing pit and fissure caries on the occlusal surfaces of primary molars in children. Nine small RCTs were included providing limited evidence of low to very low certainty.
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This review of the effectiveness of Interproximal enamel reduction (IPR) techniques used in orthodontics included 10 small studies. The included studies were small and of very low to low quality so the findings should be viewed cautiously.
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Mark-Steven Howe takes a detailed look at this review update and network meta-analyses of periodontal regenerative therapies. He highlights the inclusion of non-resorbable membrane studies that are no longer used.
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Alice Potter summarises a Wellcome Trust funded active ingredients review, which looks at how promoting helpful attention and interpretation patterns may reduce anxiety and depression in young people.
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