Drug treatment of refractory schizophrenia remains a major challenge, but clozapine continues to be gold standard

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Schizophrenia is a crippling condition that often (in about 20-30% of patients) shows an inadequate response to first-line antipsychotic drugs. Because it is associated with significant, often devastating reductions in quality of life, the management of refractory cases of schizophrenia represents a major challenge to psychiatry. As pharmacotherapy is the treatment of choice, stringent guidelines [read the full story…]

No support for peer support?

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In this blog, I’m going to be discussing a recent systematic review and meta-analysis of “peer support for people with serious mental illness” (Lloyd-Evans et al, 2014). It’s something of a personal (as well as an academic) interest, as I am a carer and have been involved in mutual peer support groups myself. I have given [read the full story…]

Off to a good start. Are self-help interventions effective for people with comorbid physical and mental health problems?

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The ideal treatment for common mental health problems in those with chronic physical illness would have to be reliable, easy to deliver, inexpensive and accessible by a group of people whose physical impairment may affect treatment adherence. NICE guidelines (CG90 Depression; the treatment and management of depression in adults) recommend self-help interventions (SHIs) based on [read the full story…]

Black patients’ first contact with mental health services is more likely to be coercive

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It is well documented that there are differences in how patients are treated, depending on their ethnicity. Previous inquiries in the UK have suggested that the NHS is institutionally racist (Blofeld et al, 2003). Some groups, for example those from African Caribbean or Aboriginal descent, experience more coercive care and poor outcomes, including higher doses of [read the full story…]

Moving to better neighbourhoods: bad for boys, good for girls?

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The link between external influences such as family and neighbourhood experiences and young people’s mental health outcomes has been extensively commented on in the literature. While it is more common for studies to focus on the individual or family level, looking at things from a wider perspective is interesting especially from a public mental health [read the full story…]

New evidence update from NICE on the prevention of problem drinking

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The National Institute for Health and Care Excellence (NICE) has recently published an evidence update focussed on preventing harmful drinking. This update builds upon previous recommendations (NICE PH24, 2010) and is aimed at increasing awareness of the latest evidence available. Furthermore, the update indicates whether any new research may have potential impact on future NICE [read the full story…]

Children of older fathers have an increased risk of psychiatric and academic problems, says new cohort study

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Research suggests that the risk of developing psychiatric problems (such as autism spectrum disorder, intellectual disability or schizophrenia) may be linked to increased paternal age at the time of conception. This seems quite plausible given that advancing age in men is associated with increased genetic mutations in sperm. However, studies so far have generally not [read the full story…]

Are there any effective interventions for preventing falls in older people with mental health problems?

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Falls are estimated to cost the NHS more than £2.3 billion per year (College of Optometrists, 2011) and are associated with significant morbidity and mortality. This fact alone should be giving us the drive to look for ways to prevent falls in healthcare settings. A systematic review recently published in BMC Nursing (Bunn et al, 2014) is [read the full story…]

New study demonstrates effectiveness of antipsychotic Pimavanserin for Parkinson’s disease psychosis

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When we think of Parkinson’s disease (PD), hallucinations and delusions are probably not the first symptoms that come to mind. And yet, it is estimated that nearly half of all patients with PD experience psychotic symptoms at one time or another. Although deficits in motor function are seen as the hallmark of PD, it is [read the full story…]

Longer adolescent duration of worry and low mood predicts problems in adulthood: suggests early intervention important

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Adolescent mental health problems are the cause of deep distress to hundreds of thousands of teenagers in the UK. Young Minds estimates that 850,000 children and young people in the UK have a diagnosed mental health problem, and many more may be suffering in silence.  Statistics on how likely it is that an adolescent with [read the full story…]