Cognitive therapy plus antidepressants for depression

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Patrick Kennedy-Williams highlights a new large-scale RCT of combined cognitive therapy plus antidepressants for major depressive disorder. The trial finds that this combination is effective, but only in patients with severe non-chronic depression.

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One new drug a week: club drugs and novel psychoactive substances

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Meg Fluharty summarises a recent report from the Royal College of Psychiatrists and explores why novel psychoactive substances and club drugs need a different response from UK treatment providers.

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Do mental health websites improve help-seeking in adolescents?

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Maxine Howard summarises the findings of a recent review of online mental health services for young people, which finds little evidence to suggest that websites increase help-seeking in adolescents.

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Long duration of untreated psychosis is associated with a range of poor outcomes

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Joe Judge appraises a recent systematic review and meta-analysis looking at the duration of untreated psychosis as a predictor of long-term outcomes in schizophrenia.

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Mental health anti-stigma programs are (broadly) successful

it is vital that such anti-stigma programs are informed by high quality research evidence

Dave Steele reports on a recent meta-analysis of mental health anti-stigma programs, which on the whole are found to be effective at reducing the stigma associated with mental disorders.

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Smoking cessation in the emergency setting

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Olivia Maynard summarises a systematic review of smoking cessation interventions in the emergency setting, which highlights the poor quality and heterogenous nature of the published trials in this field.

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Antidepressants for depression in pregnancy: new systematic review says the jury’s still out

Nikki Newhouse summarises a recent US health technology assessment of antidepressants for depression in pregnancy and the postpartum period, which concludes that the evidence remains inconclusive about the benefits and harms of antidepressants for depression in pregnancy.

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Tricyclic antidepressants for ADHD in children and adolescents: Cochrane review finds no evidence to support prescribing

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Helge Hasselman summarises a Cochrane review of tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents, which finds low quality evidence and no justification for prescribing these drugs in this group of patients.

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Medication in advanced dementia: how can we judge what is appropriate?

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Caroline Struthers appraises a recent US cross-sectional study of the use of medications of “questionable benefit” in nursing home residents with advanced dementia. She concludes that all medications are of questionable value if they have side effects which might have a negative impact on quality of life or are likely to cause harm.

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Cyberbullying and mental health in young people

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Elly O’Brien summarises a recent US survey of adolescents, which investigates the relationship between cyberbullying, mental health and substance use problems, and the moderating role of family dinners.

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