This review of adjunctive systemic or local antimicrobials as an adjunct to surgical treatment of peri-implantitis included 4 RCTs. The included studies only included a total of 200 pateints and were all considered to be at high risk of bias. The studies antimicrobial and treatment protocols also showed marked variation. Consequently, there is little evidence available on the effectiveness of local or systemic antimicrobials as adjuncts to surgical treatment of peri-implantitis