Not all childhood trauma has the same biological impact. A new study finds that adversity in late childhood is most strongly linked to immune dysregulation at age 24.
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A large NHS trial found that the Circle of Security parenting programme did not outperform treatment-as-usual for parents experiencing perinatal mental health difficulties. But does this mean we should stop offering it?
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Is teenage depression more likely to come back later in life? A new population study challenges assumptions and finds similar recurrence risks in both adolescents and adults.
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How safe is it to treat ADHD in people with schizophrenia spectrum disorders? New long-term data offers pragmatic reassurance, but also some warnings.
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Clozapine is described as the gold standard treatment for schizophrenia but a new cohort study suggests it is associated with an increased risk of infections, particularly in older patients, further solidifying the case for holistic care.
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The UPSIDES trial demonstrates that peer support is effective across diverse global contexts, from high-income to low-income countries. While overall social inclusion scores didn’t reach significance, participants showed reduced isolation and increased empowerment and hope. This landmark study proves peer support can be successfully adapted to different cultural settings while maintaining core recovery-oriented principles.
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Sex and gender differences in mental health are real; the mechanisms are under-explored. This review pulls together evidence on sex-steroids, brain development, neuroinflammation, and the social world to show where practice and policy must catch up.
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People with severe mental illness often face years of poor health before diagnosis. A new study uses machine learning and clinical notes to map the early warning networks of symptoms that could help us intervene earlier.
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Can ketamine help people with treatment-resistant depression, regardless of childhood trauma history? This new study suggests that trauma load and severity may not influence treatment outcomes.
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This big meta-analysis pooled 155 studies from 37 countries and found many more delusional themes than standard assessment tools capture. Clinicians should watch for “non-classical” content, and researchers should widen how we measure delusions.
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