Ketamine, depression and childhood trauma: new evidence from a community study

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Can ketamine help people with treatment-resistant depression, regardless of childhood trauma history? This new study suggests that trauma load and severity may not influence treatment outcomes.

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Widening the lens on delusions: a global meta-analysis shows our scales miss many common themes

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This big meta-analysis pooled 155 studies from 37 countries and found many more delusional themes than standard assessment tools capture. Clinicians should watch for “non-classical” content, and researchers should widen how we measure delusions.

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The Lancet Commission on self-harm: a global call for compassionate, culturally informed care

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Self-harm is a global public health issue, yet it remains under-recognised and poorly addressed. A landmark Lancet Commission reframes self-harm as a complex behaviour shaped by culture, society, and inequality—and sets out 12 key recommendations for change.

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Therapy through the lens of autism: what helps autistic adults feel safe and supported?

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What makes therapy feel safe and effective for autistic adults? This new qualitative study sheds light on the adjustments that matter most.

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Prescribing in borderline personality disorder: Evidence, relationships, and the realities of practice

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No drugs are officially approved for borderline personality disorder, yet prescribing is widespread. This systematic review explores why clinicians prescribe, the pressures they face, and what it means for patient care.

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Who gets included in psychedelics research? A systematic review of ethnoracial representation

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Despite psychedelics’ roots in Indigenous and minoritised communities, clinical trials overwhelmingly centre White participants. This review highlights the consequences and asks how research can change.

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Psychedelics and Queerness: Do we have a meaningful voice?

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Despite psychedelics’ deep ties with queer culture, research often excludes queer voices. This recent scoping review highlights gaps and shows how inclusive, intersectional methods can transform the field.

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The genetic link behind sleep problems, cognitive dysfunction, and neuroticism in ‘treatment-resistant depression’

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A big new study suggests that certain genetic traits—like insomnia risk and neuroticism—may make depression harder to treat, while protective traits include education and cognitive ability.

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Targeting teenage worry: network analysis of anxiety symptoms over time

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Nervousness, irritability, excessive worry, uncontrollable worry… not all anxiety symptoms weigh the same at different ages. This new Chineses study shows how anxiety networks tighten as young people grow older, and where the best intervention targets may lie.

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“Necessary evil” or hidden harm? A scoping review of informal coercion in psychiatry

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Informal coercion – the subtle pressure patients feel in psychiatric care – is common but poorly understood. A new scoping review sheds light on how it’s defined, where it happens, and why it matters for patients and professionals alike.

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