Alcohol use disorder is frequently comorbid with major depressive disorder, and the disease burden associated with this dual diagnosis is considerably greater than that attributed to each disorder in isolation. This creates a problem for clinicians who are trying to treat depressed problem drinkers, because many services are set up to deal with only one [read the full story…]
Last week the media reported widely on a study of ketamine for depression (McShane et al, 2014). As usual the headlines made bold assertions, the Telegraph running with “Horse tranquilliser Ketamine could cure severe depression” (Knapton, 2014). But what did the paper authored by an Oxford group and published in the Journal of Psychopharmacology really [read the full story…]
Depression and anxiety are both common conditions in patients with dementia and mild cognitive impairment (MCI), with some studies finding around 30% of patients show at least some depressive symptoms (Enache et al, 2011). Similarly, a study on vascular dementia found around 70% of participants had two or more symptoms of anxiety (Ballard et al, 2000). [read the full story…]
This guidance has been published and should be read alongside the Commissioning Policy A05 Complex and Specialised Obesity Surgery Services of the NHS Commissioning Board April 2013. It has been sponsored by the British Obesity and Metabolic Surgery Society, and is supported by a number of relevant professional bodies, including the Association of UK Dietitians [read the full story…]
In spite of widely available different antidepressants, major depression does not respond adequately in up to one third of patients. Overall, the need for both reliable and well-tolerated treatment has remained unmet for a sizeable proportion of people with depression. In the past couple of years, there has been controversy about the suitability of Agomelatine (Valdoxan) [read the full story…]
The fact that drug overdoses are the second largest cause of premature death from unintentional injuries in the US (for example, in 2010 there was 38,329 drug overdose deaths) is not a surprising statistic. What may surprise readers is that of these deaths 22,134 were attributed to prescription drugs. Indeed, almost one and a half [read the full story…]
People with serious mental illness (SMI) such as schizophrenia and bipolar disorder have higher morbidity and mortality rates due to physical illness. It’s estimated that people with SMI die 10-15 years earlier than the general population (DeHert et al, 2011). Increasingly attention is being paid to ways to improve the physical health of people with [read the full story…]
Despite being on the decline, smoking is still one of the largest causes of preventable morbidity and mortality in the world. According to recent World Health Organisation data, smoking directly kills around 5 million people every year. The NHS spends almost £90 million on cessation efforts to combat the £5 billion treatment cost. Recent research [read the full story…]
Antidepressant treatment is associated with a variety of side effects, including emotional changes, weight gain or fatigue. As pharmaceutical treatment has evolved, clinicians have become increasingly aware of another major adverse effect of modern antidepressants: sexual dysfunction. Current figures estimate that up to every second patient will, at some stage, experience reduced sexual function, which [read the full story…]
Orthognathic surgery for the correction of dentofacial and craniofacial deformities has become a common a common procedure. Postoperative infection rates have been reported between 2-33%. The aim of this review was to provide evidence-based recommendations on the efficacy of different antibiotic regimens in preventing postoperative infections after orthognathic surgery Searches were conducted in Embase, Ovid [read the full story…]
