Results: 121

For: medicines

Using the highs to combat the lows: ketamine-assisted therapy for anxiety and depression

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In her debut blog, Gabrielle Williams reviews a US study on the safety and effectiveness of ketamine-assisted therapy (a digital intervention combining psychotherapy, journaling and ketamine) for moderate to severe anxiety and depression.

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Third molar surgery and antibiotic use

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This review of antibiotic prophylactic treatments in relation to the risk of developing dry socket (DS) and site-specific infection (SSI) after lower third molar extraction included 16 RCTs. Antibiotic did reduce the risk of DS and SSI in health patients but the number needed to treat (NNT) was high so the use should be considered only after a careful assessment of an individual patient’s risk.

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Ketamine and suicidal ideation: French trial finds modest short-term effects

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Anya Borissova reviews a French trial that claims to be evidence that “ketamine is rapid, safe in the short term, and has persistent benefits for acute care in suicidal patients”.

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Ketamine “shows promise” as an anti-suicidal ideation agent, but will this promise ever be realised?

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Rosalind McAlpine and Karel Kieslich summarise a recent systematic review which focuses on the rapid anti-suicidal ideation effect of ketamine.

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Lamotrigine in the maintenance treatment of bipolar disorder

Lamotrigine, an anticonvulsant drug, is licensed in the United States for the maintenance treatment of bipolar I disorder and in the UK to prevent depressive episodes in bipolar disorder. Hashimoto and colleagues (2021) performed a Cochrane Intervention Review to explore whether lamotrigine is effective and safe compared to the most established maintenance treatment, lithium, and placebo.

Michael Ostacher critically appraises and summarises a recent Cochrane systematic review, which presents the latest best evidence on the efficacy of lamotrigine in the maintenance treatment of bipolar disorder.

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Peri-implantitis: Are locally administered antibiotics effective?

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This review of the effectiveness of locally administered antibiotics in the treatment of peri-implantitis included 12 small studies 7 of which were RCTs. While the findings suggest a small additional benefit with antibiotic use however the clinical importance of this is debatable.

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ADHD: which medications are most effective and safe?

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In his debut blog, Franco De Crescenzo summarises a narrative review that finds good evidence for the short-term pharmacological treatment of ADHD.

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Can ketamine metabolites and gamma power help predict clinical response for ‘treatment resistant depression’?

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Anya Borissova summarises a recent randomised placebo-controlled trial that evaluated ketamine metabolites, clinical response, and gamma power for major depression.

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Patients’ experience of ketamine treatment for depression: the ‘Ketamine and me’ project

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In her debut blog, Harmony Jiang reviews a recent qualitative study exploring patients’ experience and response to ketamine treatment for depression.

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Drug treatment of ADHD in children and young people with ASD #CAMHScampfire

Mental Health Awareness concept for ADHD. letters spelling ADHD.

Douglas Badenoch appraises an up-to-date systematic review and decision pathway for the drug treatment of ADHD symptoms in young people with autism spectrum disorder.

Follow #CAMHScampfire on Twitter at 5pm BST on Tuesday 25th May for an online journal club discussing this paper. Or sign up now to join the free webinar hosted by ACAMH.

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