The benefits and harms of antidepressants for youth depression and anxiety #ActiveIngredientsMH

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Mark Horowitz and Joanna Moncrieff consider a new #ActiveIngredientsMH review published today in The Lancet Psychiatry, which looks at the knowns and unknowns of antidepressant treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action.

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Antidepressants for youth depression: Cochrane review confirms they should not be the first port of call

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Susannah Murphy summarises a new Cochrane review and network meta-analysis, which provides the best evidence to date about new generation antidepressants for depression in children and adolescents.

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Antidepressants and psychotherapy for adolescent depression: can they be compared? #ActiveIngredientsMH

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Catherine Harmer summarises a recent network meta-analysis relating to her own Wellcome Trust funded research into antidepressants for young people with anxiety or depression.

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Psychotherapies for depression in children and adolescents: all of equal IMPACT?

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Jasmin Wertz summarises the recently published IMPACT trial, which found that CBT, short-term psychoanalytical psychotherapy and brief psychosocial interventions (psychoeducation) were all equally effective in treating depression in children and young people.

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Antidepressants: benefits and harms in children and adults

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Samei Huda discusses the findings of a recent review into suicidality and aggression during antidepressant treatment. The systematic review and meta-analyses were based on clinical study reports and included some important adverse effects of antidepressants in children and young people.

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Childhood adversity linked to psychotropic drug use in later life

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Andrew Jones summarises a large Finnish population-based cohort study, which finds that childhood adversities strongly predict the use of psychotropic drugs (such as antidepressants and antipsychotics) in adulthood.

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Collaborative care for adolescent depression: new RCT shows promise

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Jennifer Laidlaw writes her debut blog on a recent RCT in JAMA about collaborative care for adolescent depression in primary care. The trial concludes that collaborative care is both feasible and effective in improving outcomes, but Jennifer highlights a number of limitations and questions for future research.

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New evidence on antidepressants and suicide risk in children and young people

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Major depressive disorder (MDD) is unfortunately a relatively common condition in children and adolescents.  Depression is estimated to affect 2% of pre-pubertal children and 5-8% of adolescents (Son et al, 2000). As you might expect, depression has a significant negative impact on the development, functioning and risk for suicide in individuals affected, as well as [read the full story…]

Systematic review finds that tricyclics do not benefit children with depression

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Clinical depression is one of the most common mental health problems occurring in children and adolescents. It is often accompanied or followed by additional negative outcomes, including social and academic problems, anxiety and substance use. Many depressed adolescents continue to have recurring problems throughout adulthood. A variety of antidepressant drugs, such as tricyclics and selective [read the full story…]

Uncertainty over what works best to prevent relapse of childhood depression

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Much of the research about depression in children and adolescents focuses on how to treat the illness during the acute phase. This review from the Cochrane Depression, Anxiety and Neurosis Review Group is more concerned with the ways in which interventions can be used to prevent relapse or recurrence of depressive disorders. The review looks specifically at two [read the full story…]