There is a need for a rapid-acting, non-injection, acute treatment for agitation in people with schizophrenia. This randomised (double-blind, placebo-controlled, parallel-group) controlled trial set out to evaluate the effectiveness and safety of inhaled loxapine for acute treatment of agitation in schizophrenia. The researchers recruited 344 adults with DSM-IV schizophrenia who were in good general health [read the full story…]
A research team from Umeå University in Sweden have published a randomised controlled trial that investigates the importance of pacing when delivering bibliotherapy for people with panic disorder, i.e. should patients be ‘prescribed’ a full book as therapy all at once, or should they be given separate chapters each week? The small trial randomised 28 [read the full story…]
Researchers from Manchester University have conducted one of the largest randomised controlled trials ever undertaken to investigate self-harm in adolescents. The trial published in the BMJ examined the effectiveness and cost-effectiveness of group therapy for self harm in young people by randomising 366 patients to: Manual based developmental group therapy programme specifically designed for adolescents [read the full story…]
Teenagers with depression sometimes do not respond to treatment with SSRI antidepressants and this inevitably leads to a higher cost of treatment. This randomised controlled trial (conducted by researchers from Kaiser Permanente Northwest in Portland, Oregon) set out to evaluate the incremental cost-effectiveness over 24 weeks of combined cognitive behavior therapy plus switch to a different antidepressant [read the full story…]
Major depressive disorder is a prevalent and debilitating condition in elderly patients. It is accompanied by circadian rhythm disturbances associated with impaired functioning of the suprachiasmatic nucleus, the biological clock of the brain. Circadian rhythm disturbances are common in the elderly. Suprachiasmatic nucleus stimulation using bright light treatment may, therefore, improve mood, sleep, and hormonal [read the full story…]
Antipsychotic medication is widely used to treat behavioural problems in people with learning disabilities. A Cochrane review of the use of these medications for this purpose found very few randomised controlled trials (a method of clinical research in which people are allocated at random to receive a clinical intervention, a placebo, or no intervention at [read the full story…]
This randomised controlled trial published in the Journal of the American Academy of Child and Adolescent Psychiatry looks at the effectiveness of a new cognitive-behavioural parenting-based approach for treating anxiety in young children. Timid to Tiger is an entirely parenting-based approach to managing anxiety in children aged nine years or below. It is based on evidence that anxious children benefit [read the full story…]
Family Nurse Partnership is a preventive programme for vulnerable first time young mothers. It offers intensive and structured home visiting, delivered by specially trained nurses, from early pregnancy until the child is two. The Family Nurse Partnership began in England in 2007 with initial testing in 10 sites. There are now over 50 sites across [read the full story…]
Mothers living in socioeconomically deprived communities are vulnerable to anxiety and depression, but traditional medical approaches often fail to reach them. This prospective randomised controlled trial set out to compare the effectiveness of a lengthened multi-disciplinary team consultation with normal primary care in reducing anxiety and depression in mothers. Ninety four mothers were recruited from three general practices from [read the full story…]
Many published guidelines (including the American Psychiatric Association Clinical Practice Guidelines for schizophrenia), recommend second-generation antipsychotics for the treatment of depression in schizophrenia. This study compared a first-generation antipsychotic (perphenazine) with 4 second-generation antipsychotics (olanzapine, quetiapine, risperidone, and ziprasidone) and the impact these drugs had on the symptoms of depression. The authors used data from the Clinical [read the full story…]
