More research needed before polyunsaturated fatty acids can be recommended for ADHD in children and adolescents

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Drug treatments are commonly used to treat children and young people with attention deficit hyperactivity disorder (ADHD). Methylphenidate and amphetamine are two of the most popular, but these are not effective for all patients and sometimes cause problematic side effects. Children and adolescents with ADHD have been shown to have significantly lower plasma and blood [read the full story…]

Losing weight on antipsychotics. New systematic review looks at diet and exercise

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Weight gain is one of the side effects that people who take antipsychotic drugs complain of the most. Obesity is common in this population and this can often lead to cardiovascular problems and a far shorter life expectancy than the rest of the population. As a result, there is a great deal of interest in [read the full story…]

Haloperidol reduces mania a little faster than second-generation antipsychotics, according to systematic review

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There are a range of treatment options for people with bipolar disorder who are experiencing a manic episode. An important part of this treatment is to reduce the symptoms of mania and provide the individual with some level of normality. I blogged this time last year about a meta-analysis in the Lancet that showed that [read the full story…]

The dose-response association between psychological distress and mortality, new BMJ meta-analysis shows the link

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There is an increasing body of evidence showing that depression and anxiety are linked with other health conditions like cancer and cardiovascular disease. I’ve blogged about the link between depression and stroke, and there are a number of other studies that show an association between psychological distress (the symptoms of depression and anxiety) and mortality, [read the full story…]

Review finds insufficient evidence base for the view that violence, sexual, or criminal risk can be predicted

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Normally, we at the Learning Disabilities Elf like to look at learning disability specific research, but we thought this review of the utility of risk assessment tools was interesting and relevant to people with learning disabilities who come into contact with psychiatric and criminal justice services. Risk assessment research stresses the dynamic nature of predictors [read the full story…]

Risk assessment tools do not accurately predict the risk of repeat offending, according to new systematic review

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Risk assessment tools are widely used in psychiatric hospitals and criminal justice systems to help predict violent behaviour and inform sentencing and release decisions. Yet their predictive accuracy remains uncertain and expert opinion is divided, according to a new systematic review published in the BMJ. An international team of researchers led by Seena Fazel from [read the full story…]

Citalopram outperforms all other antidepressants except escitalopram for acute phase depression, according to new review

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Citalopram (brand names: Cipramil and Celexa) is an antidepressant drug in the selective serotonin reuptake inhibitor (SSRI) class. It was one of the first SSRIs to come onto the market over 20 years ago and is available as tablets and as oral drops that are taken in a juice drink. There are lots of antidepressants [read the full story…]

New Cochrane review shows that exercise helps with depression, but more research is needed

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This is perfect timing from the chaps at the Cochrane Depression, Anxiety and Neurosis Group. After all the hubbub about exercise and depression a few weeks ago, it’s great to read an updated version of their systematic review that looks at the effectiveness of exercise in the treatment of depression. The review looked for randomised [read the full story…]

Paliperidone palmitate injections for schizophrenia: new Cochrane systematic review

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We know that people with schizophrenia who adhere to their treatment are more likely to experience sustained periods of time without psychotic symptoms. However, lots of patients find it hard to stick to the prescribed medication, so doctors sometimes recommend alternative treatments to try and encourage adherence. Long-acting intramuscular injections are one option available to [read the full story…]

Extrapyramidal side effects from second-generation antipsychotic drugs: new systematic review

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The newer second-generation antipsychotic drugs (Risperidone, Quetiapine, Amisulpride, Aripiprazole, Clozapine, Olanzapine) are promoted because they have a lower risk of extrapyramidal side effects than older drugs. Drug companies often promote these newer drugs as virtually free from extrapyramidal side effects, but the patients who take them and the clinicians who prescribe them often don’t agree. [read the full story…]