This review of metformin as an adjunct to scaling and root planing for chronic periodontitis included 5 RCTs that were of limited quality and mainly from one research group. The findings suggest benefit.
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This review of the adjunctive effect of statins on mechanical periodontal therapy included 15 studies 12 of which were RCTs. The findings suggest a positive effect on probing pocket depth, clinical attachment level, and intrabony defects but the overall quality of evidence is considered to be low.
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Only 1 trial at high risk of bias was included in this recent update of a 2014 Cochrane review of periodontal therapy for preventing cardiovascular disease (CVD) providing insufficient evidence to support or refute whether periodontal therapy can prevent the recurrence of CVD in the long term in patients with chronic periodontitis.
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10 randomised trials were included in this review of he adjunctive use of statins with scaling and root planing for treatment of chronic periodontitis . The findings suggest additional benefits with their use regardless of health or smoking status.
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This review of adjunctive use of systemic antibiotics in nonsurgical periodontal treatment of diabetics identified 12 small RCTs. No additional benefit was seen with antibiotic use
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Mark-Steven Howe looks at a systematic review of the effectiveness of adjunctive antibiotics in smokers undergoing non-surgical periodontal treatment. While a statistical benefit was noted it was not considered to be clinically relevant.
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This reviews of the efficacy of periodontal maintenance treatment carried out in primary care compared to the specialist setting following specialist treatment included 8 cohort studies. The quality of the available evidence was limited suggesting outcomes may be poorer in primary care further high quality studies are required
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7 prospective cohort studies were included in this review of dental implant survival in patients with periodontitis. Patients with aggressive periodontitis has statistically significant lower survival rates at 3 years but the quality of the evidence is limited.
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4 small RCTs of probiotics as an adjunct to scaling and root planing for management of chronic periodontitis were identified for this review. While a statistical significant benefit was demonstrated the limited number of small studies means that these findings should be interpreted with caution.
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This review of the impact of furcation involvement on tooth loss in periodontal disease found 21 pro- and retrospective studies. The data suggests that the risk of tooth loss may be doubled where there is furcation involvement.
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