This Danish study of over 3 million people found that having a first-degree relative with depression increased risk 2.35-times, resulting in 15% lifetime risk (compared to 7.8% in the general population). However, 60% of depression cases occurred in people with no affected close relatives, highlighting that family history is only part of the story.
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Healthcare workers have twice the risk of fatal drug overdose compared to other workers. This study of 58 coroner reports found that occupational hazards (workplace access to drugs, clinical knowledge, prescribing power) combined with mental health problems and work stress contributed to these deaths, highlighting the need for systemic workplace interventions.
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PsyRiskMR is a new database that helps researchers investigate risk factors for common psychiatric disorders using Mendelian randomization.
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This twin study of nearly 14,000 UK adolescents found that body dissatisfaction at age 16 was linked to eating disorder symptoms at 21 and depression at 26. Comparing twins helped researchers show these were likely causal relationships, not just correlations, though genetics also played a substantial role.
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This network meta-analysis of 76 trials found that slow tapering (over 4 weeks) combined with psychological support was most effective for preventing relapse when stopping antidepressants. Abrupt discontinuation and fast tapering substantially increased relapse risk and should be avoided.
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Although a flu vaccine activated the immune system and raised cytokine levels in this randomised trial, participants didn’t feel substantially different from the placebo group. Vaccine models can help study subtle inflammation effects.
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The Co-Pact study uses powerful images and narratives from 48 people to reveal how compulsory admission under the Mental Health Act is experienced by racially minoritised communities. Participants described coercive care, institutional racism, and being “voiceless”, but also what could prevent crisis admissions.
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A growing body of research suggests that disrupted interoception and affective touch might play a role in skin-picking disorder. This blog critically examines the first systematic review to map this emerging field.
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PTSD in young people is common, complex, and often entangled with depression, anxiety, and multiple traumatic experiences. A major new UK trial (DECRYPT) tested whether a structured form of trauma-focused cognitive therapy (CT-PTSD) can work in real CAMHS settings for those with the most severe difficulties.
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Researchers pulled together evidence from more than half a million people to test a simple but important idea: if childhood maltreatment raises the risk of adult depression, could reducing maltreatment help prevent it? The answer, as always, is more complicated than it first appears.
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