Sex and gender differences in mental health are real; the mechanisms are under-explored. This review pulls together evidence on sex-steroids, brain development, neuroinflammation, and the social world to show where practice and policy must catch up.
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Can ketamine help people with treatment-resistant depression, regardless of childhood trauma history? This new study suggests that trauma load and severity may not influence treatment outcomes.
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Self-harm is a global public health issue, yet it remains under-recognised and poorly addressed. A landmark Lancet Commission reframes self-harm as a complex behaviour shaped by culture, society, and inequality—and sets out 12 key recommendations for change.
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What makes therapy feel safe and effective for autistic adults? This new qualitative study sheds light on the adjustments that matter most.
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Despite psychedelics’ roots in Indigenous and minoritised communities, clinical trials overwhelmingly centre White participants. This review highlights the consequences and asks how research can change.
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Despite psychedelics’ deep ties with queer culture, research often excludes queer voices. This recent scoping review highlights gaps and shows how inclusive, intersectional methods can transform the field.
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A big new study suggests that certain genetic traits—like insomnia risk and neuroticism—may make depression harder to treat, while protective traits include education and cognitive ability.
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Nervousness, irritability, excessive worry, uncontrollable worry… not all anxiety symptoms weigh the same at different ages. This new Chineses study shows how anxiety networks tighten as young people grow older, and where the best intervention targets may lie.
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Effective treatment for mental health disorders remains the exception rather than the rule. A new 21-country study reveals where in the treatment cascade people are most likely to drop out and which factors improve the odds of getting the care they need.
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Women with ADHD are up to 4 times more likely to experience severe premenstrual mood symptoms than those without ADHD, especially if they also live with depression or anxiety. This new UK study shines a light on a neglected area of research, and calls for better awareness, assessment, and support.
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