Results: 29

For: antibiotics

Non-surgical periodontal therapy – which antibiotic regime?

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This review of amoxicillin & metronidazole as an adjunct to non-surgical periodontal treatment included 18 trials . A small benefit was seen with antibiotic use but no clinically meaningful difference between different doses or duration of amoxicillin-plus-metronidazole at 3 months post-treatment.

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Third molar removal: antibiotics reduced risk of dry socket

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This review of antibiotic prophylaxis for the removal of third molars included 22 RCTs and suggest that antibiotic use lowered the infection risk by 60%. The number pf patients needed to treat to prevent one infection was 14 (95%CI;11-19).

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Azithromycin as an adjunctive antibiotic in non-surgical periodontal therapy

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Another new review of local or systemic azithromycin as an adjunct in non-surgical periodontal therapy includes 14 RCTs and demonstrates small benefits in periodontal parameters. However, the included studies are small and it is unclear if the benefits are clinically important.

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Antibiotic prophylaxis and dental implant failure

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This review of antibiotic prophylaxis during dental implant placement considered both systematic reviews and RCTs. Evidence from the 10 included RCTs suggests a small reduction (2%) in the risk of implant loss. These results are similar to a recent Cochrane review.

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Non-surgical periodontal treatment – is there a role for systemic antibiotics?

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This review update includes 23 new studies comparing the effects of antibiotic therapy adjunctive to scaling and root planning for periodontal disease. While some additional benefit was shown the authors could not establish definitive conclusions and guidelines regarding their use.

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Dental implant failures reduced with prophylactic antibiotic suggests review

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This new review covers similar ground to the 2013 Cochrane review. It includes non-randomised controlled trials, but as with the Cochrane review the findings suggest that antibiotics reduce early implant failure.

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Limited evidence for best antibiotic regimens to prevent postoperative infections after orthognathic surgery

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Orthognathic surgery for the correction of dentofacial and craniofacial deformities has become a common a common procedure. Postoperative infection rates have been reported between 2-33%. The aim of this review was to provide evidence-based recommendations on the efficacy of different antibiotic regimens in preventing postoperative infections after orthognathic surgery Searches were conducted in Embase, Ovid [read the full story…]

Review finds only a small benefit from antibiotic use in patients with acute sinusitis

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Sinusitis is one of the commonest reasons for visiting the doctor accounting for 15% to 21% of all adult outpatient antibiotic prescriptions. Patients may also present at dental practices, as pain from upper posterior teeth can be indistinguishable from sinusitis.  Typical signs and symptoms are purulent nasal discharge, postnasal drip, sinus pain at palpation, nasal [read the full story…]

Currently insufficient evidence to decide if antibiotics are effective in treating irreversible pulpitis

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Irreversible pulpitis often presents as an acute and intense pain and is a frequent reason for emergency dental visits.  Treatment involves accessing the root canal of the tooth to remove the inflamed pulp (nerve) and cleaning the root canal. The aim of this review was to assess the effects of systemic antibiotics for irreversible pulpitis. [read the full story…]

D-cycloserine does not improve CBT for social anxiety disorder, but may accelerate early treatment gains

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Clinical trials in the field of social anxiety to date have primarily focussed on the effect of either anxiolytic medication or cognitive behavioural therapy (CBT). At best these trials have demonstrated only moderate efficacy for either treatment independently (Davidson et al, 2004; Clark et al, 2003; Heimberg et al, 1998; Stein et al, 1998), and [read the full story…]