Review highlights need for specific models to measure quality of life for people with learning disabilities

Analysis showed significant lack of robust evidence on impact or cost effectiveness

A key indicator of service outcomes for people with learning disabilities is quality of life. However, there continues to be debate in the literature about the best way to define this and the best way to measure it. Most of the major service providers in the UK for example have some form of routine outcome [read the full story…]

Insufficient evidence to recommend tricyclic antidepressants as a treatment for autism spectrum disorders

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Young people with autism spectrum disorders (ASD) are usually given some kind of behavioural or educational intervention to help improve their overall functioning. However, in some cases, those individuals who have high levels of repetitive, obsessive-compulsive type behaviours and mood disorders are treated with drug interventions, although there is little high quality evidence to support [read the full story…]

Pharmacists can significantly improve patient adherence to antidepressants, according to new systematic review

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Observational studies (Vergouwen et al) have reported alarmingly high discontinuation rates for patients taking antidepressant medication (28% at 1 month and 44-52% at 3 months). One group of health professionals who can potentially have a major impact on this issue are pharmacists. This new systematic review conducted by researchers from Riyadh in Saudi Arabia, set [read the full story…]

Are we under-reporting suicide rates? Findings of a new systematic review

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World Health Organization statistics estimate the global annual suicide rate to be 16 per 100,000 people or about one million people per year. The rate of suicide attempts is about 10-15 times higher than the actual suicide rate. There is considerable variation between countries, with some national mortality statistics reporting no suicides per 100,000 people [read the full story…]

Systematic review finds limited evidence for the use of omega-3 fatty acids in autism spectrum disorders

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Previous research has highlighted that people with autism spectrum disorders may be deficit in omega-3 fatty acids and that taking supplements may help to improve the symptoms of the condition. This new Cochrane systematic review set out to review the efficacy of omega-3 fatty acids for improving core features of autism spectrum disorder (e.g. social [read the full story…]

Well conducted studies are urgently needed to assess the adverse effects of antipsychotics in children and young people

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There is a great deal of debate about prescribing antipsychotics to children and young people. Prescription rates of these drugs has risen sharply over the last few years, but there remains only limited evidence about the safety and efficacy of these medicines. The second-generation antipsychotics (SGAs) have become more popular and this is partly due [read the full story…]

Group CBT is an effective treatment for depression, but the evidence remains quite weak

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The NICE depression guidance recommends a stepped-care model for treating mild to moderate depression (see figure 11 below). A considerable amount of funding has gone towards the Improving Access to Psychological Therapies initiative in England, but despite this the availability of individual therapy remains limited and relatively few people with depression receive the kind of [read the full story…]

Preventing and managing violence in mental health and criminal justice populations: results of a new systematic review

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The public perception of mental health and violent behaviour has often been influenced by poor media coverage and a focus on specific crimes committed by people with psychosis. There’s a nice summary of work in this area on the Mind website, which includes a number of enlightening stats, including this one: The fear of random [read the full story…]

Functional analysis may be a promising alternative treatment for challenging behaviour in dementia

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Mood, memory and behaviour are all affected by dementia and it is not unusual for behaviour to become ‘challenging’. People with dementia may become agitated or aggressive and this can be extremely difficult and stressful for family members and carers. Challenging behaviour has traditionally been managed with antipsychotic drugs, despite the fact that they do [read the full story…]

No evidence for the use of aspirin, steroids or NSAIDs for the treatment of Alzheimer’s disease

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Alzheimer’s disease affects 1-2% of people aged 65-70 and approximately 20% of those over 80 years. As our population ages, the condition is on the increase and it’s estimated that 2030, an estimated 7.7 million Americans aged 65 and older will have Alzheimer’s disease. We do not yet know exactly how and why Alzheimer’s disease [read the full story…]