Oral cancer- monoclonal antibodies combined with standard treatment may improve outcomes

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12 trials were included in this Cochrane review of molecularly targeted therapies and immunotherapies as adjuncts to standard treatments for oral cancer. Moderate evidence was found that standard therapy plus epidermal growth factor receptor monoclonal antibody (EGFR mAb) reduced mortality and locoregional failures.

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Parasympathomimetic drugs for dry mouth after radiotherapy


The update of a 2007 Cochrane review of parasympathomimetic drugs for dry mouth after radiotherapy did not identify an new studies. The 3 RCTs identified in the previous version provide limited evidence to support the use of pilocarpine hydrochloride in the treatment of radiation-induced xerostomia.

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Review suggests that radiotherapy was associated with higher rates of implant loss


Implant–supported restorations show good success rates in healthy tissues while studies in irradiated jaws contrasting outcomes have been reported. The aim of this review was 
to assess the survival rate of titanium implants placed in irradiated jaws. The Medline, Embase, and CENTRAL, and  OpenGRAY databases were searched together with a number of journals (Clinical Implant [read the full story…]

No randomised controlled trials to support or refute the extraction or non-extraction of teeth prior to radiotherapy of head and neck

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Globally about 3% of cancers are head and neck cancers.  Dental examination and completion of any necessary treatment is recommended prior to any radiotherapy required for patients with head and neck cancer. The aim of this Cochrane review was to assess whether the pre-radiation extraction of diseased or non-diseased molars compared to conservative treatment reduced [read the full story…]

Patient factors that affect successful dental implant placement

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The use of dental implants is expanding rapidly.  Treatment planning for their placement involves the assessment of patient-related risk factors prior to formulation of a treatment plan. The aim of this review was to assess relevant literature and provide evidence-based information on the successful surgical placement of dental implants The authors conducted a search of [read the full story…]