Lidocaine: trial suggests that buffering may not improve success of inferior alveolar nerve block


A 2010 Cochrane review that was not able to include any dental studies did find that buffering lidocaine decreased pain on injection and augmented patient comfort and satisfaction. This new dental trial included 80 patients with symptomatic irreversible pulpitis but found no significant difference with success rates with buffered lidocaine.

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Bupivacaine may reduce post-operative pain in patients having single visit root canal treatment

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Elimination of pain during and after root canal treatment is an important element of patient care and modern endodontic practice.  The aim of this study was to compare the postoperative pain and analgesic use after single-visit root canal treatment of acute irreversible pulpitis with either bupivacaine (a long-acting anaesthetic) or lidocaine. Patients with a first [read the full story…]

Side effects of local anaesthetics


Local anaesthetic use is widespread in dentistry and while lidocaine has been in use for more than 50 years an increasing number of agents are now available. The aim of this study was to analyze adverse drug reactions (ADRs) associated with local anesthetics (LAs) and to characterize the safety profile of LAs in clinical application. [read the full story…]

Evidence suggests that 4% articaine provides superior pulpal anaesthesia to 2% lidocaine

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The ability to provide pain- free dentistry is important  and the American Dental Association Center for Evidence-Based Dentistry (ADA-EBD)has just published this critical summary of  a 2011 systematic review by Brandt et al . The review compares the efffecacy  of  two local anaesthetics ( 4% articaine and 2% lidocaine)   in providing successful pulpal anaesthesia. The [read the full story…]

Increasing the pH of lidocaine solution decreases pain on injection and improves patient comfort and satisfaction

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This is a critical appraisal of a Cochrane review first published in December 2010.  The appraisal was prepared under the auspices of the American Dental Associations Centre for Evidence-based Dentistry The objective of the Cochrane review was to determine if adjusting the pH of lidocaine had any effect on pain resulting from non-intravascular injections in [read the full story…]

4% articaine and 2% lidocaine with epinephrine have similar effectiveness in achieving anaesthesia in maxillary teeth

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The aim of the study was to compare the anaesthetic efficacy of buccal infiltrations of 4% articaine with epinephrine (1:100,000) and 2% lidocaine with epinephrine (1:80,000) in achieving anaesthesia in maxillary permanent teeth with irreversible pulpitis. Patients aged 16 years and over who presenting with irreversible pulpitis in one tooth and an asymptomatic vital tooth [read the full story…]