This review of the impact of smoking on clinical outcomes of non-surgical periodontal treatment included 17 cohort studies of whihc 11 were prospective. The findings suggest statistically significant smaller improvements in the smoking that non-smoking group. However, any differences are modest and my not be clinically important.
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This review of the adjunctive effects of lasers or antimicrobial photodynamic therapy (aPDT) to non-surgical periodontal treatment included 17 RCTs. The studies were small and hetrogeneous including just 701 patients in total and of low quality providing very limited evidence.
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This review of sub-gingival chlorhexidine chips as an adjunct to scaling and root planing in patients with chronic periodontitis included 15 RCTs involving 620 patients in total. Findings suggest an additional improvement with adjunctive use of chlorhexidine chips.
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This review evaluating the efficacy of subgingival instruments for the treatment of periodontitis included 19 RCTs. The findings show that mechanical subgingival instrumentation is efficacious in the nonsurgical treatment of periodontitis, irrespective of type of instrument or mode of delivery.
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4 RCTs involving 96 patients were included in this review of osseous resective surgery (ORS) in the treatment of residual periodontal defects.
The findings suggest some benefit from ORS but they should be interpreted cautiously because of the limited number of small studies.
This review of the effectiveness of adjunctive local antiseptics to conventional scaling and root planning (SRP) included 12 RCTs only 3 of whihc were considered to be at low risk of bias. While the findings suggest some benefit from the use of antiseptics with a sustained-release delivery the limited quality of the included studies means that the findings should be interpreted cautiously.
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This review of minimally invasive periodontal surgery for the treatment of intra‐bony defects included 25 studies of which 10 were randomised controlled trials. There is limitied evidence comparing minimal and traditional approach but minimal invasive surgery may produce similar outcomes.
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This review evaluating the potential efficacy of mesenchymal stem cells in periodontal regeneration included 15 small studies of very low quality. Additional high quality RCTs are neeeded to assess effectiveness before clinicial use.
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This review looked at the adjunctive effects of hyaluronic acid (HA) on surgical or non-surgical periodontal treatment. Thirteen RCTs the majority at high risk of bias suggested that the topical application of HA may lead to additional clinical benefits.
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This review of the effectiveness of systemic doxycycline as an adjunct to scaling and root planning (SRP) with SRP alone in diabetic patients with periodontitis included 6 small RCTs suggesting no additional benefit from systemic docycycline.
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