Have the EAGLES landed? Safety of varenicline, bupropion and NRT in smokers with and without mental illnesses


Paul Christiansen presents the results of the EAGLES RCT into the neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patches in smokers with and without psychiatric disorders.

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Can pharmacotherapy help smokers with severe mental disorders?


Andrew Jones reports on an ecological pragmatic clinical trial, which suggests that it is feasible to support smoking cessation in people with severe mental disorders such as bipolar disorder and schizophrenia.

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Pharmacotherapy for smoking cessation in severe mental illness


Andrew Jones reports on a recent systematic review and network meta-analysis of the efficacy and tolerability of pharmacotherapy for smoking cessation in severe mental illness, which finds a promising but low quality result for bupropion and varenicline.

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Nicotine patches, Varenicline and combination NRT: as good/bad as each other?


Paul Christiansen considers the findings of a recent RCT, which evaluates the effects of nicotine patches versus varenicline versus combination nicotine replacement therapy on smoking cessation at 26 weeks.

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Smoking and chronic mental illness: what’s the best way to quit or cut down?


Meg Fluharty considers the findings of a BMJ State of the Art review, which looks at the evidence for smoking cessation in people with chronic mental illness such as schizophrenia, unipolar depression, bipolar depression, anxiety disorders and PTSD.

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Varenicline is not associated with an increased risk of suicide or criminal behaviour

Champix Varenicline

Abi Rose summarises a recent cohort study, which concludes that the smoking cessation drug varenicline is not associated with increased risk of suicidal or criminal behaviour, and association with psychiatric disorders are likely due to other factors.  

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Promoting smoking cessation in people with schizophrenia


Meg Fluharty summarises a recent clinical overview of smoking cessation in people with severe mental illness, which provides useful practical advice to clinicians who are trying to help service users with schizophrenia, psychosis and other conditions to quit smoking

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Varenicline supports smoking reduction and smoking cessation, according to RCT


Paul Christiansen highlights an RCT of varenicline on smoking cessation through smoking reduction, which suggests that varenicline may be an effective treatment for smokers who wish to gradually reduce their cigarette consumption.

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Motivational interviewing may help people quit smoking, but more research is needed


Olivia Maynard summarises the recent Cochrane systematic review on motivational interviewing for smoking cessation, which concludes that motivational interviewing may assist people to quit smoking, but does not tell us much about the actual components of MI that optimise the success of the intervention.

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Varenicline and the risk of neuropsychiatric adverse events and death


Natasha Clarke publishes her debut Mental Elf blog about a new systematic review and meta-analysis investigating the risk of neuropsychiatric adverse events associated with the smoking cessation drug varenicline.

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