There is a great deal of debate about prescribing antipsychotics to children and young people. Prescription rates of these drugs has risen sharply over the last few years, but there remains only limited evidence about the safety and efficacy of these medicines. The second-generation antipsychotics (SGAs) have become more popular and this is partly due [read the full story…]
A number of concerns have arisen over recent years about the safety of the various drugs used to treat ADHD (Attention Deficit Hyperactivity Disorder) in children and young adults. These central nervous system stimulants include methylphenidate, dexmethylphenidate, dextroamphetamines, amphetamine salts, atomoxetine and pemoline. Case reports have highlighted that sudden cardiac death can be brought on [read the full story…]
This topic has been well publicised in recent years and for good reason. We know that there is a huge disparity between the number of people with dementia who are prescribed antipsychotics (180,000 in England each year) and the number who may derive some benefit from the treatment (36,000). We also know that dangerous side [read the full story…]
Lithium is a medicine that has been used for over 50 years to treat depression and bipolar disorder. It comes in two forms that are used clinically: lithium carbonate and lithium citrate. A certain level of the drug is needed in the blood stream for it to be effective, but if the level rises too [read the full story…]
All mental health professionals are well aware that depression and alcohol misuse frequently go hand in hand. One condition often complicates and affects the outcome of the other. NICE guidelines recommend treating the alcohol problems first and then after 3-4 weeks of abstinence focus on treating the comorbid mental illness if it’s still present. This [read the full story…]
A large number of systematic reviews and guidelines have been published in recent years to assist clinicians in prescribing the best antidepressants for treating depression. This new meta-analysis conducted by researchers from Austria and the US, sets out to compare the benefits and harms of second generation antidepressant drugs in the treatment of major depressive [read the full story…]
The aim of this study was to establish the relative safety and balance of risks for antidepressant treatment in older people. The cohort study included 60,746 patients aged 65 years and over diagnosed with depression. The study was based in 570 general practices in the UK supplying data to the QResearch database. The study objectives [read the full story…]
Antipsychotics are frequently used in the treatment of people with learning disabilities, but little is published in the literature concerning their metabolic and endocrine side-effects. The researchers in this observational study set out to compare indices of obesity, glucose, lipids and prolactin between 138 people with learning disabilities who were treated with antipsychotic medications and [read the full story…]
Benzodiazepines are most commonly prescribed for the management of anxiety and insomnia. They can also be used for sedation or amnesia before medical or surgical procedures, treatment of seizure, treatment of alcohol or sedative withdrawal, or acute agitation. Known side effects include drowsiness, fatigue and ataxia (the loss of full control of bodily movements). Opioids [read the full story…]
Depression is common in patients with dementia and antidepressants are widely prescribed for this population although the evidence remains limited. This randomised controlled trial conducted by researchers at the Institute of Psychiatry in London and published in the Lancet, explored the safety and efficacy of two widely-used drugs (sertraline and mirtazapine) in patients with dementia and [read the full story…]
